Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applications

Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applications

Natural killer cells (NK cells) are important immune cells within the tumor microenvironment (TME) and are considered the first line of defense in tumor immunity. Although many studies have focused on the role of NK cells in tumor therapy, the heterogeneity of NK cells complicates the investigation...

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Bibliographic Details
Main Authors: Mingxin Shen, Yutong Liu, Liang Shao, Meng Qu, Shixin Song, Wei Sun, Hao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
single-RNA sequencing
NK cell
heterogeneity
tumor microenvironment
drug intervention
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612352/full
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