Culture Medium Enriched with Ultrafine Carbon Monoxide Bubbles Enhances In Vitro Blastocyst Formation of In Vivo-Fertilized Mouse Zygotes

Culture Medium Enriched with Ultrafine Carbon Monoxide Bubbles Enhances In Vitro Blastocyst Formation of In Vivo-Fertilized Mouse Zygotes

Oxidative stress induced by in vitro culture conditions impedes the differentiation of fertilized zygotes. Gasotransmitters containing carbon monoxide (CO) exhibit antioxidant properties when exogenously administered at appropriate concentrations. In this study, CO was incorporated into ultrafine bu...

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Main Authors: Toyofumi Hirakawa, Kazuhiko Nakabayashi, Noriko Ito, Keisuke Ishiwata, Daichi Urushiyama, Kohei Miyata, Tsukasa Baba, Kenichiro Hata, Shin’ichiro Yasunaga, Fusanori Yotsumoto, Katsuro Tachibana, Shingo Miyamoto
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antioxidants
Subjects:
gasotransmitter
carbon monoxide
ultrafine bubble
blastocyst
Online Access:https://www.mdpi.com/2076-3921/14/6/684
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