Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the Literature
Neuroblastoma is the third most commonly occurring malignancy of the pediatric population, although it is extremely rare in the adult population. In adults, neuroblastoma is often metastatic and portends an extremely poor overall survival. Our case report documents metastatic neuroblastoma occurring...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/341980 |
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| _version_ | 1832545615659139072 |
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| author | Patrick L. Stevens Douglas B. Johnson Mary Ann Thompson Vicki L. Keedy Haydar A. Frangoul Kristen M. Snyder |
| author_facet | Patrick L. Stevens Douglas B. Johnson Mary Ann Thompson Vicki L. Keedy Haydar A. Frangoul Kristen M. Snyder |
| author_sort | Patrick L. Stevens |
| collection | DOAJ |
| description | Neuroblastoma is the third most commonly occurring malignancy of the pediatric population, although it is extremely rare in the adult population. In adults, neuroblastoma is often metastatic and portends an extremely poor overall survival. Our case report documents metastatic neuroblastoma occurring in a healthy 29-year-old woman whose course was complicated by an unusual presentation of elevated intracranial pressures. The patient was treated with systemic chemotherapy, I131 metaiodobenzylguanidine (MIBG) radiotherapy, and autologous stem cell transplant (SCT). Unfortunately the patient’s response to therapy was limited and she subsequently died. We aim to review neuroblastoma in the context of increased intracranial pressure and the limited data of neuroblastoma occurring in the adult population, along with proposed treatment options. |
| format | Article |
| id | doaj-art-f74e1a4fdf0045e4aabc8f068b316a8c |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-f74e1a4fdf0045e4aabc8f068b316a8c2025-02-03T07:25:25ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/341980341980Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the LiteraturePatrick L. Stevens0Douglas B. Johnson1Mary Ann Thompson2Vicki L. Keedy3Haydar A. Frangoul4Kristen M. Snyder5Divisions of Hematology and Oncology, Department of Medicine, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USADivisions of Hematology and Oncology, Department of Medicine, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Pathology, Microbiology, and Immunology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USADivisions of Hematology and Oncology, Department of Medicine, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USADivision of Pediatric Hematology and Oncology, Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center 2220 Pierce Avenue, 397 PRB, Nashville, TN 37232-6310, USADivision of Pediatric Hematology and Oncology, Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center 2220 Pierce Avenue, 397 PRB, Nashville, TN 37232-6310, USANeuroblastoma is the third most commonly occurring malignancy of the pediatric population, although it is extremely rare in the adult population. In adults, neuroblastoma is often metastatic and portends an extremely poor overall survival. Our case report documents metastatic neuroblastoma occurring in a healthy 29-year-old woman whose course was complicated by an unusual presentation of elevated intracranial pressures. The patient was treated with systemic chemotherapy, I131 metaiodobenzylguanidine (MIBG) radiotherapy, and autologous stem cell transplant (SCT). Unfortunately the patient’s response to therapy was limited and she subsequently died. We aim to review neuroblastoma in the context of increased intracranial pressure and the limited data of neuroblastoma occurring in the adult population, along with proposed treatment options.http://dx.doi.org/10.1155/2014/341980 |
| spellingShingle | Patrick L. Stevens Douglas B. Johnson Mary Ann Thompson Vicki L. Keedy Haydar A. Frangoul Kristen M. Snyder Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the Literature |
| title_full | Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the Literature |
| title_fullStr | Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the Literature |
| title_full_unstemmed | Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the Literature |
| title_short | Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the Literature |
| title_sort | adult neuroblastoma complicated by increased intracranial pressure a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2014/341980 |
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