Exome sequencing reveals low-frequency and rare variant contributions to multiple sclerosis susceptibility in Turkish families

Exome sequencing reveals low-frequency and rare variant contributions to multiple sclerosis susceptibility in Turkish families

Abstract Multiple sclerosis (MS) is characterized as an immune-mediated central nervous system disease marked by chronic inflammation, demyelination, and progressive neurodegeneration. In this study, we evaluated the contribution of low-frequency and rare genetic variants to MS susceptibility within...

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Main Authors: Furkan Büyükgöl, Berk Gürdamar, Mehmet Ufuk Aluçlu, Yeşim Beckmann, Kaya Bilguvar, Cavit Boz, Alper Bülbül, Sena Destan Bünül, Özge Çetin, Caner Feyzi Demir, Serkan Demir, Taşkın Duman, Hüsnü Efendi, Özgül Ekmekçi, Utku Ertetik, Özlem Ethemoğlu, Elif Everest, Haluk Gümüş, Tuncay Gündüz, Rana Karabudak, Bedriye Karaman, Murat Kürtüncü, Muzaffer Mutluer, Meziyet Dilara Reda, Sabahattin Saip, Meral Seferoğlu, Elif Sever, Osman Ugur Sezerman, Sedat Şen, Beril Taşdelen, Mehmet Tecellioğlu, Murat Terzi, Aslı Tuncer, Ömer Faruk Turan, Melih Tütüncü, Gülgün Uncu, Uğur Uygunoğlu, Cihat Uzunköprü, Umut Voyvoda, Mehmet Fatih Yetkin, Nur Yüceyar, Aksel Siva, Eda Tahir Turanlı
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Genetics
Familial multiple sclerosis
Blood–brain barrier
Whole exome sequencing
Online Access:https://doi.org/10.1038/s41598-025-94691-x
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