CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS
Pulmonary hypertension (PH) in pediatrics is a polygenic multifactorial condition with extremely adverse prognosis. Selection of optimal management is a severe task. In absence of treatment the mean life duration in children is not higher one year. Last two decades, revolution in approaches to treat...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2018-04-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/805 |
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| author | I. M. Miklashevich М. A. Shkolnikova S. V. Gorbachevsky A. A. Shmalts О. S. Groznova D. I. Sadykova L. V. Yakovleva D. N. Degtyarev A. A. Burov D. Yu. Ovsyannikov A. V. Volkov |
| author_facet | I. M. Miklashevich М. A. Shkolnikova S. V. Gorbachevsky A. A. Shmalts О. S. Groznova D. I. Sadykova L. V. Yakovleva D. N. Degtyarev A. A. Burov D. Yu. Ovsyannikov A. V. Volkov |
| author_sort | I. M. Miklashevich |
| collection | DOAJ |
| description | Pulmonary hypertension (PH) in pediatrics is a polygenic multifactorial condition with extremely adverse prognosis. Selection of optimal management is a severe task. In absence of treatment the mean life duration in children is not higher one year. Last two decades, revolution in approaches to treatment improved the survival of this patients group. Recently, pediatricians and pediatric cardiologists have three drugs groups that act on the main pathogenetic chains of PH: endothelin pathway, nitric oxide pathway and prostacyclin pathway. At the moment, approaches to pediatric PH are based on the data obtained in the trials on adult patients. However, not long ago there were first randomized trials on children performed. The group of authors of current article presents a modern view on the problem of PH in children, and expert recommendations on children management. Class of recommendations and evidence level were set by the data obtained in pediatric population or on adult population with at least 10% of children included. To the strategy, developed by the Russian clinicians, laid the analysis of experience of the pathology treatment in Russian Federation, as the current practics and clinical guidelines on pediatric PH in Europe, and the recent trials published. |
| format | Article |
| id | doaj-art-f736459f956d49d8a65fe34666bd114d |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2018-04-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-f736459f956d49d8a65fe34666bd114d2025-08-20T03:18:46Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252018-04-0117210112410.15829/1728-8800-2018-2-101-124554CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICSI. M. Miklashevich0М. A. Shkolnikova1S. V. Gorbachevsky2A. A. Shmalts3О. S. Groznova4D. I. Sadykova5L. V. Yakovleva6D. N. Degtyarev7A. A. Burov8D. Yu. Ovsyannikov9A. V. Volkov10Veltishchev ScientificResearch Clinical Institute of Pediatrics of the Pirogov RNRMUVeltishchev ScientificResearch Clinical Institute of Pediatrics of the Pirogov RNRMUBakulev Scientific Center of CardiosurgeryBakulev Scientific Center of CardiosurgeryVeltishchev ScientificResearch Clinical Institute of Pediatrics of the Pirogov RNRMUKazanskaya State Medical AcademyBashkirskiy State Medical UniversityKulakov Scientific Center of Obstetrics, Gynecology and PerinatologyKulakov Scientific Center of Obstetrics, Gynecology and PerinatologyRUDN UniversityNasonova ScientificResearch Center of RheumatologyPulmonary hypertension (PH) in pediatrics is a polygenic multifactorial condition with extremely adverse prognosis. Selection of optimal management is a severe task. In absence of treatment the mean life duration in children is not higher one year. Last two decades, revolution in approaches to treatment improved the survival of this patients group. Recently, pediatricians and pediatric cardiologists have three drugs groups that act on the main pathogenetic chains of PH: endothelin pathway, nitric oxide pathway and prostacyclin pathway. At the moment, approaches to pediatric PH are based on the data obtained in the trials on adult patients. However, not long ago there were first randomized trials on children performed. The group of authors of current article presents a modern view on the problem of PH in children, and expert recommendations on children management. Class of recommendations and evidence level were set by the data obtained in pediatric population or on adult population with at least 10% of children included. To the strategy, developed by the Russian clinicians, laid the analysis of experience of the pathology treatment in Russian Federation, as the current practics and clinical guidelines on pediatric PH in Europe, and the recent trials published.https://cardiovascular.elpub.ru/jour/article/view/805childrenpulmonary hypertensionheart failuremedicationsrandomized controlled studyatrial septostomy (atrioseptostomy), potts anastomosis |
| spellingShingle | I. M. Miklashevich М. A. Shkolnikova S. V. Gorbachevsky A. A. Shmalts О. S. Groznova D. I. Sadykova L. V. Yakovleva D. N. Degtyarev A. A. Burov D. Yu. Ovsyannikov A. V. Volkov CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS Кардиоваскулярная терапия и профилактика children pulmonary hypertension heart failure medications randomized controlled study atrial septostomy (atrioseptostomy), potts anastomosis |
| title | CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS |
| title_full | CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS |
| title_fullStr | CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS |
| title_full_unstemmed | CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS |
| title_short | CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS |
| title_sort | contemporary strategy of pulmonary hypertension management in pediatrics |
| topic | children pulmonary hypertension heart failure medications randomized controlled study atrial septostomy (atrioseptostomy), potts anastomosis |
| url | https://cardiovascular.elpub.ru/jour/article/view/805 |
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