Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironment

Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironment

Abstract Background Heat stroke, caused by excessive heat production or impaired dissipation, often results from prolonged heat exposure or strenuous activity. Ferroptosis, a novel form of programmed cell death, has been implicated in its pathogenesis, though its mechanisms remain unclear. Objective...

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Bibliographic Details
Main Authors: Defeng Yin, Qin Guo, Hao Jiang, Yonglan Hu, Lu Liu, Xiang Li, Chenglin Wang, Shilin Li, Kaiyu Jin, Yingchun Hu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medical Genomics
Subjects:
Heat stroke
Ferroptosis
WGCNA
Single-Cell sequencing
Pseudotime analysis
Online Access:https://doi.org/10.1186/s12920-025-02188-3
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