Minibeam Spatially-Fractionated Radiation Therapy Is Superior to Uniform Dose Radiation Therapy for Abscopal Effect When Combined with PD-L1 Checkpoint Inhibitor Immunotherapy in a Dual Tumor Murine Mammary Carcinoma Model

Minibeam Spatially-Fractionated Radiation Therapy Is Superior to Uniform Dose Radiation Therapy for Abscopal Effect When Combined with PD-L1 Checkpoint Inhibitor Immunotherapy in a Dual Tumor Murine Mammary Carcinoma Model

Spatially fractionated radiation therapy (SFRT) has a long history of treating bulky and hypoxic tumors. Recent evidence suggests that, compared to conventional uniform dose radiation therapy, SFRT may utilize different mechanisms of tumor cell killing, potentially including bystander and immune-act...

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Bibliographic Details
Main Authors: Judith N. Rivera, Keith Laemont, Artak Tovmasyan, Stefan Stryker, Kenneth Young, Theresa Charity, Gregory M. Palmer, Sha Chang
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Radiation
Subjects:
radiation therapy
immune therapy
minibeam radiation therapy
spatially fractionated radiation therapy
immune checkpoint inhibitor
Online Access:https://www.mdpi.com/2673-592X/5/1/3
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