Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review.
<h4>Background</h4>The goal of this study was to perform a systematic review to examine the efficacy and safety of various salvage therapy regimens on patients with relapsed/refractory PTCL.<h4>Method</h4>The electronic searches were performed using PubMed, Cochrane Library,...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0161811 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849707455580209152 |
|---|---|
| author | Ya-Ting Yang Cheng-Jeng Tai Chiehfeng Chen Hong-Cheng Wu Natalia Mikhaylichenko Hsien-Tsai Chiu Yun-Yi Chen Yi-Hsin Elsa Hsu |
| author_facet | Ya-Ting Yang Cheng-Jeng Tai Chiehfeng Chen Hong-Cheng Wu Natalia Mikhaylichenko Hsien-Tsai Chiu Yun-Yi Chen Yi-Hsin Elsa Hsu |
| author_sort | Ya-Ting Yang |
| collection | DOAJ |
| description | <h4>Background</h4>The goal of this study was to perform a systematic review to examine the efficacy and safety of various salvage therapy regimens on patients with relapsed/refractory PTCL.<h4>Method</h4>The electronic searches were performed using PubMed, Cochrane Library, EMBASE, and Web of Science from inception through June 2015, with search terms related to relapsed/refractory PTCL, salvage chemotherapy regimens, and clinical trials. An eligible study met the following inclusion criteria: (1) Patients had refractory or relapsed PTCL; (2) drug regimens were used for salvage therapy; (3) the study was a clinical trial; (4) the study reported on a series of at least 10 patients of PTCL.<h4>Results</h4>Of 35 records identified, a total of 14 studies were eligible for systematic reviews, and 12 different salvage regimens were investigated. A total of 618 relapsed/refractory PTCL patients were identified. The ORRs ranged from 22% for those treated with lenalidomide to 86% for those with brentuximab vedotin. By the three most frequent subtypes, the ORRs ranged from 14.2% to 71.5% for patients with the PTCL-NOS subtype, 8% to 54% for AITL subtypes, and 24% to 86% for the ALCL subtype. The medians of DOR, PFS, and OS ranged from 2.5 to 16.6 months, 2.6 to 13.3 months, and 3.6 to 14.5 months, respectively. The most frequently reported grade 3 or 4 adverse events (AEs) were hematological AEs, such as neutropenia and thrombocytopenia.<h4>Conclusion</h4>The efficacy of salvage therapy regimens is highly diverse for patients with relapsed/refractory PTCL; this heterogeneity in therapeutic effects might be due to the diversity in mechanisms, PTCL subtype distribution, and/or numbers/profiles of prior therapy. Comparative studies with matched pair analysis are warranted for more evidence of the salvage treatment effect on relapsed or heavily pretreated patients with PTCL. |
| format | Article |
| id | doaj-art-f6ffaa7d11924243bbbbbebfb1ba6771 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-f6ffaa7d11924243bbbbbebfb1ba67712025-08-20T03:15:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016181110.1371/journal.pone.0161811Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review.Ya-Ting YangCheng-Jeng TaiChiehfeng ChenHong-Cheng WuNatalia MikhaylichenkoHsien-Tsai ChiuYun-Yi ChenYi-Hsin Elsa Hsu<h4>Background</h4>The goal of this study was to perform a systematic review to examine the efficacy and safety of various salvage therapy regimens on patients with relapsed/refractory PTCL.<h4>Method</h4>The electronic searches were performed using PubMed, Cochrane Library, EMBASE, and Web of Science from inception through June 2015, with search terms related to relapsed/refractory PTCL, salvage chemotherapy regimens, and clinical trials. An eligible study met the following inclusion criteria: (1) Patients had refractory or relapsed PTCL; (2) drug regimens were used for salvage therapy; (3) the study was a clinical trial; (4) the study reported on a series of at least 10 patients of PTCL.<h4>Results</h4>Of 35 records identified, a total of 14 studies were eligible for systematic reviews, and 12 different salvage regimens were investigated. A total of 618 relapsed/refractory PTCL patients were identified. The ORRs ranged from 22% for those treated with lenalidomide to 86% for those with brentuximab vedotin. By the three most frequent subtypes, the ORRs ranged from 14.2% to 71.5% for patients with the PTCL-NOS subtype, 8% to 54% for AITL subtypes, and 24% to 86% for the ALCL subtype. The medians of DOR, PFS, and OS ranged from 2.5 to 16.6 months, 2.6 to 13.3 months, and 3.6 to 14.5 months, respectively. The most frequently reported grade 3 or 4 adverse events (AEs) were hematological AEs, such as neutropenia and thrombocytopenia.<h4>Conclusion</h4>The efficacy of salvage therapy regimens is highly diverse for patients with relapsed/refractory PTCL; this heterogeneity in therapeutic effects might be due to the diversity in mechanisms, PTCL subtype distribution, and/or numbers/profiles of prior therapy. Comparative studies with matched pair analysis are warranted for more evidence of the salvage treatment effect on relapsed or heavily pretreated patients with PTCL.https://doi.org/10.1371/journal.pone.0161811 |
| spellingShingle | Ya-Ting Yang Cheng-Jeng Tai Chiehfeng Chen Hong-Cheng Wu Natalia Mikhaylichenko Hsien-Tsai Chiu Yun-Yi Chen Yi-Hsin Elsa Hsu Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review. PLoS ONE |
| title | Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review. |
| title_full | Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review. |
| title_fullStr | Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review. |
| title_full_unstemmed | Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review. |
| title_short | Highly Diverse Efficacy of Salvage Treatment Regimens for Relapsed or Refractory Peripheral T-Cell Lymphoma: A Systematic Review. |
| title_sort | highly diverse efficacy of salvage treatment regimens for relapsed or refractory peripheral t cell lymphoma a systematic review |
| url | https://doi.org/10.1371/journal.pone.0161811 |
| work_keys_str_mv | AT yatingyang highlydiverseefficacyofsalvagetreatmentregimensforrelapsedorrefractoryperipheraltcelllymphomaasystematicreview AT chengjengtai highlydiverseefficacyofsalvagetreatmentregimensforrelapsedorrefractoryperipheraltcelllymphomaasystematicreview AT chiehfengchen highlydiverseefficacyofsalvagetreatmentregimensforrelapsedorrefractoryperipheraltcelllymphomaasystematicreview AT hongchengwu highlydiverseefficacyofsalvagetreatmentregimensforrelapsedorrefractoryperipheraltcelllymphomaasystematicreview AT nataliamikhaylichenko highlydiverseefficacyofsalvagetreatmentregimensforrelapsedorrefractoryperipheraltcelllymphomaasystematicreview AT hsientsaichiu highlydiverseefficacyofsalvagetreatmentregimensforrelapsedorrefractoryperipheraltcelllymphomaasystematicreview AT yunyichen highlydiverseefficacyofsalvagetreatmentregimensforrelapsedorrefractoryperipheraltcelllymphomaasystematicreview AT yihsinelsahsu highlydiverseefficacyofsalvagetreatmentregimensforrelapsedorrefractoryperipheraltcelllymphomaasystematicreview |