Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report
Photodynamic therapy (PDT) is a treatment that combines a photosensitive drug with light to induce phototoxic response in target cells, primarily through singlet oxygen.. Few cases have reported the combination of PDT with antifungal agents to successfully treat Candida infection. We present a case...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024005027 |
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| author | Lulu Wang Yahui Feng Sisi Wang Leyao Shi Yong Ren Zhiya Yang Dongmei Shi |
| author_facet | Lulu Wang Yahui Feng Sisi Wang Leyao Shi Yong Ren Zhiya Yang Dongmei Shi |
| author_sort | Lulu Wang |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a treatment that combines a photosensitive drug with light to induce phototoxic response in target cells, primarily through singlet oxygen.. Few cases have reported the combination of PDT with antifungal agents to successfully treat Candida infection. We present a case of cutaneous mass caused by Candida albicans (C.albicans) treated solely with 5-aminolevulinic acid (ALA)- PDT. A 21-year-old female presented with a cutaneous lesion on her right elbow,. characterized by erythema, nodules, and cysts that had persisted for 3 months after surgical excision. The diagnosis of infectious granulomas caused by C. albicans was confirmed through tissue histopathological, morphology and molecular sequence of the isolated pathogen. The lesion was completely resolved after two sessions of ALA-PDT adminstered 9 days apart. During the 6-month follow-up, there were no signs of relapse. This case suggested that mono-ALA-PDT can be an effective treatment option for single lesion on the body surface caused by C. albicans deep infection. |
| format | Article |
| id | doaj-art-f6fe18eb5c584d2e925aec4b673bae43 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-f6fe18eb5c584d2e925aec4b673bae432025-02-01T04:11:48ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104466Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case reportLulu Wang0Yahui Feng1Sisi Wang2Leyao Shi3Yong Ren4Zhiya Yang5Dongmei Shi6Shandong University of Traditional Chinese Medicine, Jinan, Shandong, PR ChinaDepartment of Dermatoalogy, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR China; Laboratory of Medical Mycology, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR ChinaDepartment of Dermatoalogy, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR China; Laboratory of Medical Mycology, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR ChinaDepartment of Dermatoalogy, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR China; Laboratory of Medical Mycology, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR ChinaDepartment of Dermatology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, PR ChinaDepartment of Dermatoalogy, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR China; Laboratory of Medical Mycology, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR ChinaDepartment of Dermatoalogy, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR China; Laboratory of Medical Mycology, Jining No 1 People's Hospital, Jining 272067, Shandong Province, PR China; Corresponding author at: Dermatology Department of the First People's Hospital of Jining, Shandong, 272011, PR China.Photodynamic therapy (PDT) is a treatment that combines a photosensitive drug with light to induce phototoxic response in target cells, primarily through singlet oxygen.. Few cases have reported the combination of PDT with antifungal agents to successfully treat Candida infection. We present a case of cutaneous mass caused by Candida albicans (C.albicans) treated solely with 5-aminolevulinic acid (ALA)- PDT. A 21-year-old female presented with a cutaneous lesion on her right elbow,. characterized by erythema, nodules, and cysts that had persisted for 3 months after surgical excision. The diagnosis of infectious granulomas caused by C. albicans was confirmed through tissue histopathological, morphology and molecular sequence of the isolated pathogen. The lesion was completely resolved after two sessions of ALA-PDT adminstered 9 days apart. During the 6-month follow-up, there were no signs of relapse. This case suggested that mono-ALA-PDT can be an effective treatment option for single lesion on the body surface caused by C. albicans deep infection.http://www.sciencedirect.com/science/article/pii/S15721000240050275-aminolevulinic acid-photodynamic therapy (ALA-PDT)Candida albicans (C.albicans)Cutaneous infectious granulomaPhotodynamic Therapy |
| spellingShingle | Lulu Wang Yahui Feng Sisi Wang Leyao Shi Yong Ren Zhiya Yang Dongmei Shi Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report Photodiagnosis and Photodynamic Therapy 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) Candida albicans (C.albicans) Cutaneous infectious granuloma Photodynamic Therapy |
| title | Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report |
| title_full | Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report |
| title_fullStr | Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report |
| title_full_unstemmed | Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report |
| title_short | Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report |
| title_sort | successful management of recurrent cutaneous granulomas caused by candida albicans using aminolevulinic acid photodynamic therapy post surgery a case report |
| topic | 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) Candida albicans (C.albicans) Cutaneous infectious granuloma Photodynamic Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024005027 |
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