The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity

Summary: Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we investigate how individual glycolytic reactions determine the pathogenicity of T helper 17 (Th17) cells using Compass, an algorithm we previously...

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Bibliographic Details
Main Authors: Chao Wang, Allon Wagner, Johannes Fessler, David DeTomaso, Sarah Zaghouani, Yulin Zhou, Kerry Pierce, Raymond A. Sobel, Clary Clish, Nir Yosef, Vijay K. Kuchroo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005704
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