Research advances on receptors associated with acne pathogenesis
Acne is a multifactorial chronic inflammatory skin disease and its pathogenesis has not been fully elucidated. Various receptors have been found to be associated with acne pathogenesis. Inhibitors targeting these receptors can be used for acne treatment. For example, antihistamines reduce the releas...
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2025-06-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.06.012 |
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| _version_ | 1849411268684808192 |
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| author | LIN Yuqiu NIE Wenjia LI Guang LI Shiyang |
| author_facet | LIN Yuqiu NIE Wenjia LI Guang LI Shiyang |
| author_sort | LIN Yuqiu |
| collection | DOAJ |
| description | Acne is a multifactorial chronic inflammatory skin disease and its pathogenesis has not been fully elucidated. Various receptors have been found to be associated with acne pathogenesis. Inhibitors targeting these receptors can be used for acne treatment. For example, antihistamines reduce the release of inflammatory mediators and squalene in sebocytes, thereby preventing scarring. Androgen receptor antagonists suppress the production of downstream inflammatory factors and decrease sebum secretion. Downregulating Toll-like receptors (TLRs) inhibits inflammation and immune responses. This paper reviews the role of receptors involved in inflammatory responses and sebum secretion in acne. |
| format | Article |
| id | doaj-art-f6fcf1094a9e4428b70aa2ec354fbbcb |
| institution | Kabale University |
| issn | 1674-8468 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj-art-f6fcf1094a9e4428b70aa2ec354fbbcb2025-08-20T03:34:49Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682025-06-0132644945410.3969/j.issn.1674-8468.2025.06.012Research advances on receptors associated with acne pathogenesisLIN Yuqiu0NIE Wenjia1LI Guang2LI Shiyang3Dermatology Hospital of Jiangxi ProvinceDermatology Hospital of Jiangxi ProvinceDermatology Hospital of Jiangxi ProvinceFirst Affiliated Hospital of Nanchang University, Nanchang 330001, ChinaAcne is a multifactorial chronic inflammatory skin disease and its pathogenesis has not been fully elucidated. Various receptors have been found to be associated with acne pathogenesis. Inhibitors targeting these receptors can be used for acne treatment. For example, antihistamines reduce the release of inflammatory mediators and squalene in sebocytes, thereby preventing scarring. Androgen receptor antagonists suppress the production of downstream inflammatory factors and decrease sebum secretion. Downregulating Toll-like receptors (TLRs) inhibits inflammation and immune responses. This paper reviews the role of receptors involved in inflammatory responses and sebum secretion in acne.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.06.012acnehistamine receptorandrogen receptortoll-like receptorsfibroblast growth factor receptorliver x receptormelanocortin receptor |
| spellingShingle | LIN Yuqiu NIE Wenjia LI Guang LI Shiyang Research advances on receptors associated with acne pathogenesis Pifu-xingbing zhenliaoxue zazhi acne histamine receptor androgen receptor toll-like receptors fibroblast growth factor receptor liver x receptor melanocortin receptor |
| title | Research advances on receptors associated with acne pathogenesis |
| title_full | Research advances on receptors associated with acne pathogenesis |
| title_fullStr | Research advances on receptors associated with acne pathogenesis |
| title_full_unstemmed | Research advances on receptors associated with acne pathogenesis |
| title_short | Research advances on receptors associated with acne pathogenesis |
| title_sort | research advances on receptors associated with acne pathogenesis |
| topic | acne histamine receptor androgen receptor toll-like receptors fibroblast growth factor receptor liver x receptor melanocortin receptor |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.06.012 |
| work_keys_str_mv | AT linyuqiu researchadvancesonreceptorsassociatedwithacnepathogenesis AT niewenjia researchadvancesonreceptorsassociatedwithacnepathogenesis AT liguang researchadvancesonreceptorsassociatedwithacnepathogenesis AT lishiyang researchadvancesonreceptorsassociatedwithacnepathogenesis |