Experience in using secukinumab in patients with axial psoriatic arthritis
Axial skeletal injury is observed in 25–70% of patients with psoriatic arthritis (PsA). Spondylitis frequently occurs subclinically, which leads to serious structural and functional disorders over time. An update shows that axial skeleton involvement in PsA is characterized by a more severe clinical...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2020-11-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/1082 |
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| author | E. E. Gubar Yu. L. Korsakova E. Yu. Loginova T. V. Korotaeva |
| author_facet | E. E. Gubar Yu. L. Korsakova E. Yu. Loginova T. V. Korotaeva |
| author_sort | E. E. Gubar |
| collection | DOAJ |
| description | Axial skeletal injury is observed in 25–70% of patients with psoriatic arthritis (PsA). Spondylitis frequently occurs subclinically, which leads to serious structural and functional disorders over time. An update shows that axial skeleton involvement in PsA is characterized by a more severe clinical course: these patients are observed to have a greater severity of peripheral arthritis, enthesitis, and dactylitis, skin and nail psoriasis, a higher CRP level, and worse functional status. In addition, the disease is more severe according to the patients' subjective assessment, as evidenced by questionnaires. Synthetic disease-modifying antirheumatic drugs used to treat peripheral PsA are not recommended for axial injury. When nonsteroidal anti-inflammatory drugs are ineffective, biological drugs (tumor necrosis factor-α inhibitors or interleukin-17A (IL-17A) inhibitors) should be prescribed immediately to patients with psoriatic spondylitis. The paper describes two clinical cases demonstrating the successful use of the IL-17A inhibitor secukinumab (SEC) in patients with axial PsA (axPsA). Given the positive experience with SEC in real clinical practice, it seems reasonable to prescribe it to patients at earlier stages of axPsA. |
| format | Article |
| id | doaj-art-f6fb99a30a9145eabb45f41c7ff04507 |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2020-11-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-f6fb99a30a9145eabb45f41c7ff045072025-08-20T03:20:58ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2020-11-0114415015610.14412/1996-7012-2020-4-150-1562310Experience in using secukinumab in patients with axial psoriatic arthritisE. E. Gubar0Yu. L. Korsakova1E. Yu. Loginova2T. V. Korotaeva3V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyAxial skeletal injury is observed in 25–70% of patients with psoriatic arthritis (PsA). Spondylitis frequently occurs subclinically, which leads to serious structural and functional disorders over time. An update shows that axial skeleton involvement in PsA is characterized by a more severe clinical course: these patients are observed to have a greater severity of peripheral arthritis, enthesitis, and dactylitis, skin and nail psoriasis, a higher CRP level, and worse functional status. In addition, the disease is more severe according to the patients' subjective assessment, as evidenced by questionnaires. Synthetic disease-modifying antirheumatic drugs used to treat peripheral PsA are not recommended for axial injury. When nonsteroidal anti-inflammatory drugs are ineffective, biological drugs (tumor necrosis factor-α inhibitors or interleukin-17A (IL-17A) inhibitors) should be prescribed immediately to patients with psoriatic spondylitis. The paper describes two clinical cases demonstrating the successful use of the IL-17A inhibitor secukinumab (SEC) in patients with axial PsA (axPsA). Given the positive experience with SEC in real clinical practice, it seems reasonable to prescribe it to patients at earlier stages of axPsA.https://mrj.ima-press.net/mrj/article/view/1082axial psoriatic arthritissecukinumab (cosentyx) |
| spellingShingle | E. E. Gubar Yu. L. Korsakova E. Yu. Loginova T. V. Korotaeva Experience in using secukinumab in patients with axial psoriatic arthritis Современная ревматология axial psoriatic arthritis secukinumab (cosentyx) |
| title | Experience in using secukinumab in patients with axial psoriatic arthritis |
| title_full | Experience in using secukinumab in patients with axial psoriatic arthritis |
| title_fullStr | Experience in using secukinumab in patients with axial psoriatic arthritis |
| title_full_unstemmed | Experience in using secukinumab in patients with axial psoriatic arthritis |
| title_short | Experience in using secukinumab in patients with axial psoriatic arthritis |
| title_sort | experience in using secukinumab in patients with axial psoriatic arthritis |
| topic | axial psoriatic arthritis secukinumab (cosentyx) |
| url | https://mrj.ima-press.net/mrj/article/view/1082 |
| work_keys_str_mv | AT eegubar experienceinusingsecukinumabinpatientswithaxialpsoriaticarthritis AT yulkorsakova experienceinusingsecukinumabinpatientswithaxialpsoriaticarthritis AT eyuloginova experienceinusingsecukinumabinpatientswithaxialpsoriaticarthritis AT tvkorotaeva experienceinusingsecukinumabinpatientswithaxialpsoriaticarthritis |