Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the Literature
We report a case of pure white cell aplasia (PWCA) postthymoma resection in a 74-year-old male presenting with a 2-week history of fevers, night sweats, and severe febrile neutropenia. His pure white cell aplasia was treated with intravenous immunoglobulin (IVIg), granulocyte colony-stimulating fact...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/8271069 |
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| author | Michael Youssef Tyler W. Stratton Reid C. Gallant Christine Young Daniel Y. Li Siavash Piran |
| author_facet | Michael Youssef Tyler W. Stratton Reid C. Gallant Christine Young Daniel Y. Li Siavash Piran |
| author_sort | Michael Youssef |
| collection | DOAJ |
| description | We report a case of pure white cell aplasia (PWCA) postthymoma resection in a 74-year-old male presenting with a 2-week history of fevers, night sweats, and severe febrile neutropenia. His pure white cell aplasia was treated with intravenous immunoglobulin (IVIg), granulocyte colony-stimulating factor (G-CSF), prednisone, and cyclosporine with a mixed response. He also developed immune thrombocytopenia, which responded well to a short course of eltrombopag. With continued cyclosporine treatment, his platelet counts were stable after stopping eltrombopag. The patient's cyclosporine treatment was complicated by renal failure, resulting in cessation of cyclosporine. His PWCA and immune thrombocytopenia significantly worsened after stopping cyclosporine, and unfortunately, he died from multiorgan failure and sepsis. |
| format | Article |
| id | doaj-art-f6ec3f4bfa2e4a0682e0a117a81734fe |
| institution | OA Journals |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-f6ec3f4bfa2e4a0682e0a117a81734fe2025-08-20T02:22:46ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/8271069Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the LiteratureMichael Youssef0Tyler W. Stratton1Reid C. Gallant2Christine Young3Daniel Y. Li4Siavash Piran5Faculty of MedicineSchulich School of Medicine & DentistryFaculty of MedicineDepartment of PharmacyDepartment of Laboratory Medicine and PathobiologyDepartment of MedicineWe report a case of pure white cell aplasia (PWCA) postthymoma resection in a 74-year-old male presenting with a 2-week history of fevers, night sweats, and severe febrile neutropenia. His pure white cell aplasia was treated with intravenous immunoglobulin (IVIg), granulocyte colony-stimulating factor (G-CSF), prednisone, and cyclosporine with a mixed response. He also developed immune thrombocytopenia, which responded well to a short course of eltrombopag. With continued cyclosporine treatment, his platelet counts were stable after stopping eltrombopag. The patient's cyclosporine treatment was complicated by renal failure, resulting in cessation of cyclosporine. His PWCA and immune thrombocytopenia significantly worsened after stopping cyclosporine, and unfortunately, he died from multiorgan failure and sepsis.http://dx.doi.org/10.1155/2022/8271069 |
| spellingShingle | Michael Youssef Tyler W. Stratton Reid C. Gallant Christine Young Daniel Y. Li Siavash Piran Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the Literature Case Reports in Hematology |
| title | Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the Literature |
| title_full | Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the Literature |
| title_fullStr | Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the Literature |
| title_full_unstemmed | Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the Literature |
| title_short | Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the Literature |
| title_sort | pure white cell aplasia and immune thrombocytopenia after thymoma resection a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2022/8271069 |
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