Development of a non-derivatized LC-MS/MS method for simultaneous quantification of ten neurotransmitters in five neuroinflammatory mouse models

Development of a non-derivatized LC-MS/MS method for simultaneous quantification of ten neurotransmitters in five neuroinflammatory mouse models

Sensitive and comprehensive measurement of systemic metabolites of Trp, Phe and Glu in biological samples is effective for understanding the pathogenesis of pain, anxiety, depression, PTSD and other neurological diseases. This study developed a LC-MS/MS method for simultaneous monitoring the 10 neur...

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Bibliographic Details
Main Authors: Bao Sun, Zhaodi Xia, Chen Wang, Mengyao Wu, Ru Tie, Yilin Ru, Yaxi Meng, Lu Bai, Ying Zhang, Pu Jia, Shixiang Wang, Bing Qi, Xiaohui Zheng
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Talanta Open
Subjects:
Neurotransmitter
LC-MS/MS
Chronic pain
Anxiety
Depression
PTSD
Online Access:http://www.sciencedirect.com/science/article/pii/S2666831925000517
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