Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies

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Main Authors: Benjamin Thiele, Paul Schmidt-Barbo, Christoph Schultheiss, Edith Willscher, Thomas Weber, Mascha Binder
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56395-8
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author Benjamin Thiele
Paul Schmidt-Barbo
Christoph Schultheiss
Edith Willscher
Thomas Weber
Mascha Binder
author_facet Benjamin Thiele
Paul Schmidt-Barbo
Christoph Schultheiss
Edith Willscher
Thomas Weber
Mascha Binder
author_sort Benjamin Thiele
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publisher Nature Portfolio
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spelling doaj-art-f6e608caeb2e4b50a0c2da2b622e75812025-02-02T12:33:36ZengNature PortfolioNature Communications2041-17232025-01-011611410.1038/s41467-025-56395-8Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapiesBenjamin Thiele0Paul Schmidt-Barbo1Christoph Schultheiss2Edith Willscher3Thomas Weber4Mascha Binder5Department of Biomedicine, Translational Immuno-Oncology, University and University Hospital BaselDepartment of Biomedicine, Translational Immuno-Oncology, University and University Hospital BaselDepartment of Biomedicine, Translational Immuno-Oncology, University and University Hospital BaselInternal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-WittenbergInternal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-WittenbergDepartment of Biomedicine, Translational Immuno-Oncology, University and University Hospital Baselhttps://doi.org/10.1038/s41467-025-56395-8
spellingShingle Benjamin Thiele
Paul Schmidt-Barbo
Christoph Schultheiss
Edith Willscher
Thomas Weber
Mascha Binder
Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies
Nature Communications
title Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies
title_full Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies
title_fullStr Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies
title_full_unstemmed Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies
title_short Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies
title_sort oligoclonality of trbc1 and trbc2 in t cell lymphomas as mechanism of primary resistance to trbc directed car t cell therapies
url https://doi.org/10.1038/s41467-025-56395-8
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