Regulation of RPE65 expression in human retinal pigment epithelium cells

Regulation of RPE65 expression in human retinal pigment epithelium cells

Abstract The visual cycle is an important pathway in the retinal pigment epithelium (RPE) which regenerates 11-cis retinal chromophore for the retinal photoreceptors. The central enzyme in the visual cycle is RPE65 retinol isomerase. Expression of RPE65 mRNA and protein levels are significantly lowe...

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Bibliographic Details
Main Authors: Olga A. Postnikova, Samuel William, Sheetal Uppal, Steven L. Bernstein, Eugenia Poliakov, Igor B. Rogozin, T. Michael Redmond
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Retinal pigment epithelium
Retina
RPE65
Transcription
Translation
Ribosome
Online Access:https://doi.org/10.1038/s41598-025-12926-3
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