Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiome
Summary: Diabetes related macroangiopathy (DMA) is a major complication of type 2 diabetes (T2D), impacting both morbidity and mortality. This study characterized the gut bacteriome and mycobiome in 179 adults, including 58 with DMA, 71 with T2D, and 50 healthy controls. The gut microbiome of DMA su...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225011174 |
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| author | Xiaoling Gou Yuqing Chen Yi Zong Xuemei Huang Yihong Shen Lijie Wang Yifan Liu Yuchi He Jialong Jia Xiyu Zhang Sihan Peng Xianhua Zhou Ya Liu Jing Zhang Gang Fan |
| author_facet | Xiaoling Gou Yuqing Chen Yi Zong Xuemei Huang Yihong Shen Lijie Wang Yifan Liu Yuchi He Jialong Jia Xiyu Zhang Sihan Peng Xianhua Zhou Ya Liu Jing Zhang Gang Fan |
| author_sort | Xiaoling Gou |
| collection | DOAJ |
| description | Summary: Diabetes related macroangiopathy (DMA) is a major complication of type 2 diabetes (T2D), impacting both morbidity and mortality. This study characterized the gut bacteriome and mycobiome in 179 adults, including 58 with DMA, 71 with T2D, and 50 healthy controls. The gut microbiome of DMA subjects exhibited reduced alpha diversity, and a distinct microbial composition compared with healthy control. Two bacterial families, six bacterial genera, and four bacterial species exhibited significant differences between DMA and T2D subjects. Additionally, in the mycobiome group, Xylariales was significantly decreased in DMA subjects compared with T2D subjects. Disruptions in transkingdom interactions between gut bacteria and fungi supported microbiota dysbiosis in DMA. A diagnostic model combining bacterial and fungal markers achieved an AUC of 94.20%. This work deepens our understanding of the microbial landscape associated with macroangiopathy in diabetes and highlights potential microbial targets for diagnostics and therapeutic intervention. |
| format | Article |
| id | doaj-art-f6dc439fab4e4f7eb7879008c65aafd3 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-f6dc439fab4e4f7eb7879008c65aafd32025-08-20T03:26:51ZengElsevieriScience2589-00422025-07-0128711285610.1016/j.isci.2025.112856Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiomeXiaoling Gou0Yuqing Chen1Yi Zong2Xuemei Huang3Yihong Shen4Lijie Wang5Yifan Liu6Yuchi He7Jialong Jia8Xiyu Zhang9Sihan Peng10Xianhua Zhou11Ya Liu12Jing Zhang13Gang Fan14State Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine and Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine and Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine and Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine and Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine and Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine and Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. China; Corresponding authorState Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine and Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China; Corresponding authorState Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine and Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China; Corresponding authorSummary: Diabetes related macroangiopathy (DMA) is a major complication of type 2 diabetes (T2D), impacting both morbidity and mortality. This study characterized the gut bacteriome and mycobiome in 179 adults, including 58 with DMA, 71 with T2D, and 50 healthy controls. The gut microbiome of DMA subjects exhibited reduced alpha diversity, and a distinct microbial composition compared with healthy control. Two bacterial families, six bacterial genera, and four bacterial species exhibited significant differences between DMA and T2D subjects. Additionally, in the mycobiome group, Xylariales was significantly decreased in DMA subjects compared with T2D subjects. Disruptions in transkingdom interactions between gut bacteria and fungi supported microbiota dysbiosis in DMA. A diagnostic model combining bacterial and fungal markers achieved an AUC of 94.20%. This work deepens our understanding of the microbial landscape associated with macroangiopathy in diabetes and highlights potential microbial targets for diagnostics and therapeutic intervention.http://www.sciencedirect.com/science/article/pii/S2589004225011174Biological sciencesMicrobiome |
| spellingShingle | Xiaoling Gou Yuqing Chen Yi Zong Xuemei Huang Yihong Shen Lijie Wang Yifan Liu Yuchi He Jialong Jia Xiyu Zhang Sihan Peng Xianhua Zhou Ya Liu Jing Zhang Gang Fan Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiome iScience Biological sciences Microbiome |
| title | Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiome |
| title_full | Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiome |
| title_fullStr | Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiome |
| title_full_unstemmed | Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiome |
| title_short | Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiome |
| title_sort | disturbance of gut microbiota in diabetes related macroangiopathy evidence from the gut bacteriome and mycobiome |
| topic | Biological sciences Microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225011174 |
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