Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism
Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/572405 |
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| _version_ | 1832554873269256192 |
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| author | Annelies Peeters Myriam Baes |
| author_facet | Annelies Peeters Myriam Baes |
| author_sort | Annelies Peeters |
| collection | DOAJ |
| description | Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. By using PPAR𝛼 ligands and PPAR𝛼−/− mice, several crucial genes were shown to be regulated by PPAR𝛼 in a direct or indirect way. We here review recent evidence that PPAR𝛼 contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents. |
| format | Article |
| id | doaj-art-f6b5345cf3cc4aff87f98c92b00644fb |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-f6b5345cf3cc4aff87f98c92b00644fb2025-02-03T05:50:23ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/572405572405Role of PPAR𝛼 in Hepatic Carbohydrate MetabolismAnnelies Peeters0Myriam Baes1Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U.Leuven, Campus Gasthuisberg O/N2, 3000 Leuven, BelgiumLaboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U.Leuven, Campus Gasthuisberg O/N2, 3000 Leuven, BelgiumTight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. By using PPAR𝛼 ligands and PPAR𝛼−/− mice, several crucial genes were shown to be regulated by PPAR𝛼 in a direct or indirect way. We here review recent evidence that PPAR𝛼 contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents.http://dx.doi.org/10.1155/2010/572405 |
| spellingShingle | Annelies Peeters Myriam Baes Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism PPAR Research |
| title | Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism |
| title_full | Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism |
| title_fullStr | Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism |
| title_full_unstemmed | Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism |
| title_short | Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism |
| title_sort | role of ppar𝛼 in hepatic carbohydrate metabolism |
| url | http://dx.doi.org/10.1155/2010/572405 |
| work_keys_str_mv | AT anneliespeeters roleofpparαinhepaticcarbohydratemetabolism AT myriambaes roleofpparαinhepaticcarbohydratemetabolism |