Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism
Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/572405 |
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| Summary: | Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. By using PPAR𝛼 ligands and PPAR𝛼−/− mice, several crucial genes were shown to be regulated by PPAR𝛼 in a direct or indirect way. We here review recent evidence that PPAR𝛼 contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents. |
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| ISSN: | 1687-4757 1687-4765 |