Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy

Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy

Currently, no approved antiviral drugs target dengue virus (DENV) infection, leaving treatment reliant on supportive care. DENV vaccine efficacy varies depending on the vaccine type, the circulating serotype, and vaccine coverage. We investigated defective interfering particles (DIPs) and lipid nano...

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Bibliographic Details
Main Authors: Min-Hsuan Lin, Pramila Maniam, Dongsheng Li, Bing Tang, Cameron R. Bishop, Andreas Suhrbier, Lucy Wales- Earl, Yaman Tayyar, Nigel A.J. McMillan, Li Li, David Harrich
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
defective
interfering
RNA
DIPs
LNPs
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124003111
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