A comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures
Background: This study aimed to compare the efficacy of Denosumab (DEN) versus Zoledronic acid (ZOL) in treating patients with osteoporotic vertebral compression fractures (OVCF) after percutaneous kyphoplasty (PKP). Methods: In this study, 128 OVCF patients who underwent PKP in our hospital from Ju...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| author | Gao Shouda Zhang Lijun Liu Liyan Meng Jiayin |
| author_facet | Gao Shouda Zhang Lijun Liu Liyan Meng Jiayin |
| author_sort | Gao Shouda |
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| description | Background: This study aimed to compare the efficacy of Denosumab (DEN) versus Zoledronic acid (ZOL) in treating patients with osteoporotic vertebral compression fractures (OVCF) after percutaneous kyphoplasty (PKP). Methods: In this study, 128 OVCF patients who underwent PKP in our hospital from June 2019 to August 2022 were selected and randomized into a DEN group treated with DEN and a ZOL group treated with ZOL. Bone mineral density (BMD), bone metabolism, pain, and lumbar mobility were compared between the two groups before and after treatment, and the anterior vertebral height and local kyphotic angle were measured. Finally, the one-year refracture rate and treatment cost were counted. Results: The two groups showed no notable difference in pain, lumbar mobility, anterior vertebral height, and local kyphotic angle after treatment (P>0.050). BMD was higher in the DEN group at 6 and 12 months after treatment, while b isomer of C-terminal telopeptide of type I collagen (b-CTX) was lower (P<0.050). No statistical inter-group difference was identified in the one-year re-fracture rate (P>0.050), while the total treatment cost was lower in the DEN group compared with ZOL group (P<0.050). Conclusions: DEN and ZOL effectively improve the prognosis of OVCF patients after PKP, but DEN can more significantly improve BMD and bone metabolism with higher economic benefits. |
| format | Article |
| id | doaj-art-f6aca4ebcce941cea6ff0653be29fa85 |
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| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
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| series | Journal of Medical Biochemistry |
| spelling | doaj-art-f6aca4ebcce941cea6ff0653be29fa852025-08-20T01:54:57ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144226927610.5937/jomb0-520841452-82582502269GA comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fracturesGao Shouda0Zhang Lijun1Liu Liyan2Meng Jiayin3The Fifth People's Hospital of Jinan, Department of Orthopedics, Jinan, ChinaThe Fifth People's Hospital of Jinan, Department of Orthopedics, Jinan, ChinaThe Fifth People's Hospital of Jinan, Department of Nephropathy, Jinan, ChinaJinan Second People's Hospital, Department of Pharmaceutical, Jinan, ChinaBackground: This study aimed to compare the efficacy of Denosumab (DEN) versus Zoledronic acid (ZOL) in treating patients with osteoporotic vertebral compression fractures (OVCF) after percutaneous kyphoplasty (PKP). Methods: In this study, 128 OVCF patients who underwent PKP in our hospital from June 2019 to August 2022 were selected and randomized into a DEN group treated with DEN and a ZOL group treated with ZOL. Bone mineral density (BMD), bone metabolism, pain, and lumbar mobility were compared between the two groups before and after treatment, and the anterior vertebral height and local kyphotic angle were measured. Finally, the one-year refracture rate and treatment cost were counted. Results: The two groups showed no notable difference in pain, lumbar mobility, anterior vertebral height, and local kyphotic angle after treatment (P>0.050). BMD was higher in the DEN group at 6 and 12 months after treatment, while b isomer of C-terminal telopeptide of type I collagen (b-CTX) was lower (P<0.050). No statistical inter-group difference was identified in the one-year re-fracture rate (P>0.050), while the total treatment cost was lower in the DEN group compared with ZOL group (P<0.050). Conclusions: DEN and ZOL effectively improve the prognosis of OVCF patients after PKP, but DEN can more significantly improve BMD and bone metabolism with higher economic benefits.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502269G.pdfosteoporotic vertebral compression fracturesserum bone alkaline phosphatase (bap)total procollagen type 1 amino-terminal propeptide (tp1np)bone gamma carboxy-glutamic acid containing proteins (bgp)denosumabzoledronic acidbone mineral densityclinical safetyeconomic benefits |
| spellingShingle | Gao Shouda Zhang Lijun Liu Liyan Meng Jiayin A comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures Journal of Medical Biochemistry osteoporotic vertebral compression fractures serum bone alkaline phosphatase (bap) total procollagen type 1 amino-terminal propeptide (tp1np) bone gamma carboxy-glutamic acid containing proteins (bgp) denosumab zoledronic acid bone mineral density clinical safety economic benefits |
| title | A comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures |
| title_full | A comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures |
| title_fullStr | A comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures |
| title_full_unstemmed | A comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures |
| title_short | A comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures |
| title_sort | comparative analysis of denosumab and zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures |
| topic | osteoporotic vertebral compression fractures serum bone alkaline phosphatase (bap) total procollagen type 1 amino-terminal propeptide (tp1np) bone gamma carboxy-glutamic acid containing proteins (bgp) denosumab zoledronic acid bone mineral density clinical safety economic benefits |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502269G.pdf |
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