Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma
Chronic active EBV infection is a rare disorder prone for misdiagnosis. They present with a wide range of symptoms from indolent to aggressive clinical course. Clinico-pathological correlation with confirmation by ancillary techniques is inevitable to diagnose this disease. We present a case of a 29...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_774_22 |
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| author | Shilpi Thakur Manish Soneja Deepam Pushpam Saumyaranjan Mallick |
| author_facet | Shilpi Thakur Manish Soneja Deepam Pushpam Saumyaranjan Mallick |
| author_sort | Shilpi Thakur |
| collection | DOAJ |
| description | Chronic active EBV infection is a rare disorder prone for misdiagnosis. They present with a wide range of symptoms from indolent to aggressive clinical course. Clinico-pathological correlation with confirmation by ancillary techniques is inevitable to diagnose this disease. We present a case of a 29-year-old male with fever, weight loss, and lymphadenopathy for 6 months. Lymph node biopsy showed occasional granuloma with preserved architecture. Suspected to have tuberculosis, he received antitubercular treatment (ATT) with no response for 3 months. Subsequently, additional workup showed many EBV-positive cells in sinusoids with high serum EBV titer, confirming the difficult diagnosis of CAEBV. The present case highlights the difficulty in the diagnosis of this entity and also emphasizes the necessity to recognize this disorder in countries endemic for tuberculosis, as it is no longer bound by ethnicity and geographical boundaries. |
| format | Article |
| id | doaj-art-f699ba42a55943cf9a95800aefce2dec |
| institution | OA Journals |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-f699ba42a55943cf9a95800aefce2dec2025-08-20T02:09:14ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302025-01-0168115515710.4103/ijpm.ijpm_774_22Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigmaShilpi ThakurManish SonejaDeepam PushpamSaumyaranjan MallickChronic active EBV infection is a rare disorder prone for misdiagnosis. They present with a wide range of symptoms from indolent to aggressive clinical course. Clinico-pathological correlation with confirmation by ancillary techniques is inevitable to diagnose this disease. We present a case of a 29-year-old male with fever, weight loss, and lymphadenopathy for 6 months. Lymph node biopsy showed occasional granuloma with preserved architecture. Suspected to have tuberculosis, he received antitubercular treatment (ATT) with no response for 3 months. Subsequently, additional workup showed many EBV-positive cells in sinusoids with high serum EBV titer, confirming the difficult diagnosis of CAEBV. The present case highlights the difficulty in the diagnosis of this entity and also emphasizes the necessity to recognize this disorder in countries endemic for tuberculosis, as it is no longer bound by ethnicity and geographical boundaries.https://journals.lww.com/10.4103/ijpm.ijpm_774_22chronic infectionebvlymphomat/nk lpdtuberculosis |
| spellingShingle | Shilpi Thakur Manish Soneja Deepam Pushpam Saumyaranjan Mallick Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma Indian Journal of Pathology and Microbiology chronic infection ebv lymphoma t/nk lpd tuberculosis |
| title | Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma |
| title_full | Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma |
| title_fullStr | Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma |
| title_full_unstemmed | Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma |
| title_short | Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma |
| title_sort | chronic active epstein barr virus infection mimicking tuberculosis a diagnostic enigma |
| topic | chronic infection ebv lymphoma t/nk lpd tuberculosis |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_774_22 |
| work_keys_str_mv | AT shilpithakur chronicactiveepsteinbarrvirusinfectionmimickingtuberculosisadiagnosticenigma AT manishsoneja chronicactiveepsteinbarrvirusinfectionmimickingtuberculosisadiagnosticenigma AT deepampushpam chronicactiveepsteinbarrvirusinfectionmimickingtuberculosisadiagnosticenigma AT saumyaranjanmallick chronicactiveepsteinbarrvirusinfectionmimickingtuberculosisadiagnosticenigma |