Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain
Bone cancer pain (BCP) is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone metastasis. BCP impairs patients’ quality of life. Depending upon clinical observations, the administration of centrally acting analgesic has been associated with the alleviation of pain symptoms...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000474 |
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| author | Liqun Duan Qianliang Wang Jianpeng Chen Zelin Fan Wenzhi Zhang Jun Yan |
| author_facet | Liqun Duan Qianliang Wang Jianpeng Chen Zelin Fan Wenzhi Zhang Jun Yan |
| author_sort | Liqun Duan |
| collection | DOAJ |
| description | Bone cancer pain (BCP) is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone metastasis. BCP impairs patients’ quality of life. Depending upon clinical observations, the administration of centrally acting analgesic has been associated with the alleviation of pain symptoms BCP patients. Central nervous system sensitization performs a crucial role in pain-regulating perception in BCP. Nevertheless, the precise neural circuitry and mechanism of action remain enigmatic. In the present study, we observed the activation of glutamatergic neurons in the Prelimbic cortex (mPFC) and paraventricular thalamus (PVT) in BCP mice. Experimental validation using viral tracers confirmed the existence of a projection pathway between the PVT and mPFC. Inhibition of the input from PVT glutamatergic neurons to mPFC glutamatergic neurons alleviates chronic pain in BCP, whereas activation of the PVTGlu-mPFCGlu projection induces chronic pain in mice. These findings imply a pivotal role for the PVTGlu-mPFCGlu circuit in the regulation of chronic pain in BCP. |
| format | Article |
| id | doaj-art-f68ca90b64f4449ba10d809f72dfa41d |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-f68ca90b64f4449ba10d809f72dfa41d2025-02-09T04:59:39ZengElsevierBrain Research Bulletin1873-27472025-03-01222111235Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer painLiqun Duan0Qianliang Wang1Jianpeng Chen2Zelin Fan3Wenzhi Zhang4Jun Yan5Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, ChinaDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Corresponding authors.Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; Corresponding authors.Bone cancer pain (BCP) is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone metastasis. BCP impairs patients’ quality of life. Depending upon clinical observations, the administration of centrally acting analgesic has been associated with the alleviation of pain symptoms BCP patients. Central nervous system sensitization performs a crucial role in pain-regulating perception in BCP. Nevertheless, the precise neural circuitry and mechanism of action remain enigmatic. In the present study, we observed the activation of glutamatergic neurons in the Prelimbic cortex (mPFC) and paraventricular thalamus (PVT) in BCP mice. Experimental validation using viral tracers confirmed the existence of a projection pathway between the PVT and mPFC. Inhibition of the input from PVT glutamatergic neurons to mPFC glutamatergic neurons alleviates chronic pain in BCP, whereas activation of the PVTGlu-mPFCGlu projection induces chronic pain in mice. These findings imply a pivotal role for the PVTGlu-mPFCGlu circuit in the regulation of chronic pain in BCP.http://www.sciencedirect.com/science/article/pii/S0361923025000474Bone cancer painParaventricular nucleus of the hypothalamusPrelimbic cortexGlutamatergic neuronNeural circuit |
| spellingShingle | Liqun Duan Qianliang Wang Jianpeng Chen Zelin Fan Wenzhi Zhang Jun Yan Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain Brain Research Bulletin Bone cancer pain Paraventricular nucleus of the hypothalamus Prelimbic cortex Glutamatergic neuron Neural circuit |
| title | Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain |
| title_full | Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain |
| title_fullStr | Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain |
| title_full_unstemmed | Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain |
| title_short | Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain |
| title_sort | unraveling the pvtglu mpfcglu circuit a new frontier in chronic pain management for bone cancer pain |
| topic | Bone cancer pain Paraventricular nucleus of the hypothalamus Prelimbic cortex Glutamatergic neuron Neural circuit |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000474 |
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