Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population
To investigate the association of MET SNPs with gender disparity in thyroid tumors, as well as the metastasis and prognosis of patients, 858 patients with papillary thyroid carcinoma (PTC), 556 patients with nodular goiter, and 896 population-based normal controls were recruited. The genotyping of M...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/405217 |
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| author | Lifeng Ning Yaqin Yu Xiaoli Liu Lizhe Ai Xin Zhang Wenwang Rao Jieping Shi Hui Sun Qiong Yu |
| author_facet | Lifeng Ning Yaqin Yu Xiaoli Liu Lizhe Ai Xin Zhang Wenwang Rao Jieping Shi Hui Sun Qiong Yu |
| author_sort | Lifeng Ning |
| collection | DOAJ |
| description | To investigate the association of MET SNPs with gender disparity in thyroid tumors, as well as the metastasis and prognosis of patients, 858 patients with papillary thyroid carcinoma (PTC), 556 patients with nodular goiter, and 896 population-based normal controls were recruited. The genotyping of MET SNPs was carried out using the Sequenom MassARRAY system. The distribution of MET SNPs (rs1621 and rs6566) was different among groups. Gender stratification analysis revealed a significant association between the rs1621 genotype and PTC in female patients (P=0.037), but not in male patients (P>0.05). For female patients, the rs1621 AG genotype was significantly higher in patients with PTC than in normal controls (P=0.01) and revealed an increasing risk of PTC (OR: 1.465, 95% CI: 1.118–1.92). However, association analysis of the rs1621 genotype with metastasis and prognosis revealed no significant correlation in both male and female patients. The findings of our study showed that polymorphism of SNP locus rs1621 in MET gene may be associated with gender disparity in PTC. Higher AG genotypes in rs1621 were correlated with PTC in female patients, but not in male patients. |
| format | Article |
| id | doaj-art-f688b751194e498497c9382c0445b7c5 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f688b751194e498497c9382c0445b7c52025-02-03T01:02:57ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/405217405217Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese PopulationLifeng Ning0Yaqin Yu1Xiaoli Liu2Lizhe Ai3Xin Zhang4Wenwang Rao5Jieping Shi6Hui Sun7Qiong Yu8Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaJilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaJilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaTo investigate the association of MET SNPs with gender disparity in thyroid tumors, as well as the metastasis and prognosis of patients, 858 patients with papillary thyroid carcinoma (PTC), 556 patients with nodular goiter, and 896 population-based normal controls were recruited. The genotyping of MET SNPs was carried out using the Sequenom MassARRAY system. The distribution of MET SNPs (rs1621 and rs6566) was different among groups. Gender stratification analysis revealed a significant association between the rs1621 genotype and PTC in female patients (P=0.037), but not in male patients (P>0.05). For female patients, the rs1621 AG genotype was significantly higher in patients with PTC than in normal controls (P=0.01) and revealed an increasing risk of PTC (OR: 1.465, 95% CI: 1.118–1.92). However, association analysis of the rs1621 genotype with metastasis and prognosis revealed no significant correlation in both male and female patients. The findings of our study showed that polymorphism of SNP locus rs1621 in MET gene may be associated with gender disparity in PTC. Higher AG genotypes in rs1621 were correlated with PTC in female patients, but not in male patients.http://dx.doi.org/10.1155/2015/405217 |
| spellingShingle | Lifeng Ning Yaqin Yu Xiaoli Liu Lizhe Ai Xin Zhang Wenwang Rao Jieping Shi Hui Sun Qiong Yu Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population International Journal of Endocrinology |
| title | Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population |
| title_full | Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population |
| title_fullStr | Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population |
| title_full_unstemmed | Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population |
| title_short | Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population |
| title_sort | association analysis of met gene polymorphism with papillary thyroid carcinoma in a chinese population |
| url | http://dx.doi.org/10.1155/2015/405217 |
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