Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma
Abstract Background Altered lipid metabolism is involved in the development of many tumors. However, the role of dissimilar lipid metabolism in head and neck squamous cell carcinoma (HNSCC) is not fully established. Aims Here, we sought to determine the prognostic value of lipid metabolism‐related g...
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.379 |
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| author | Ying Xiong Yu Si Yisi Feng Shipei Zhuo Bozhen Cui Zhigang Zhang |
| author_facet | Ying Xiong Yu Si Yisi Feng Shipei Zhuo Bozhen Cui Zhigang Zhang |
| author_sort | Ying Xiong |
| collection | DOAJ |
| description | Abstract Background Altered lipid metabolism is involved in the development of many tumors. However, the role of dissimilar lipid metabolism in head and neck squamous cell carcinoma (HNSCC) is not fully established. Aims Here, we sought to determine the prognostic value of lipid metabolism‐related genes in HNSCC. Methods RNA‐seq data and clinical features of 545 HNSCC cases were obtained from The Cancer Genome Atlas database. A regulatory network of transcription factors‐lipid metabolism genes and a risk prognostic model of lipid metabolism‐related genes was developed using bioinformatics and Cox regression modeling. We used tumor immune estimation resource to analyze immune cell infiltration in patients with HNSCC based on the prognostic index (PI) of lipid metabolism‐related genes. Results A total of 136 differentially expressed lipid metabolism genes were identified. Of these, 23 are related to prognosis. In addition to predicting HNSCC prognosis, 11 lipid metabolism‐related genes (ARSI, CYP27B1, CYP2D6, DGKG, DHCR7, LPIN1, PHYH, PIP5K1B, PLA2G2D, RDH16, and TRIB3) also affect HNSCC clinical features (stage, gender, and pathological stage). The PI of lipid metabolism‐related genes embodied the state of HNSCC tumor immune microenvironment. |
| format | Article |
| id | doaj-art-f67f9589753f47ddaaddeb4a7ebd5e6d |
| institution | DOAJ |
| issn | 2050-4527 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-f67f9589753f47ddaaddeb4a7ebd5e6d2025-08-20T03:06:15ZengWileyImmunity, Inflammation and Disease2050-45272021-03-019119620910.1002/iid3.379Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinomaYing Xiong0Yu Si1Yisi Feng2Shipei Zhuo3Bozhen Cui4Zhigang Zhang5Department of Otolaryngology Head and Neck Surgery, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Otolaryngology Head and Neck Surgery, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong ChinaAbstract Background Altered lipid metabolism is involved in the development of many tumors. However, the role of dissimilar lipid metabolism in head and neck squamous cell carcinoma (HNSCC) is not fully established. Aims Here, we sought to determine the prognostic value of lipid metabolism‐related genes in HNSCC. Methods RNA‐seq data and clinical features of 545 HNSCC cases were obtained from The Cancer Genome Atlas database. A regulatory network of transcription factors‐lipid metabolism genes and a risk prognostic model of lipid metabolism‐related genes was developed using bioinformatics and Cox regression modeling. We used tumor immune estimation resource to analyze immune cell infiltration in patients with HNSCC based on the prognostic index (PI) of lipid metabolism‐related genes. Results A total of 136 differentially expressed lipid metabolism genes were identified. Of these, 23 are related to prognosis. In addition to predicting HNSCC prognosis, 11 lipid metabolism‐related genes (ARSI, CYP27B1, CYP2D6, DGKG, DHCR7, LPIN1, PHYH, PIP5K1B, PLA2G2D, RDH16, and TRIB3) also affect HNSCC clinical features (stage, gender, and pathological stage). The PI of lipid metabolism‐related genes embodied the state of HNSCC tumor immune microenvironment.https://doi.org/10.1002/iid3.379HNSCClipid metabolismPITCGA |
| spellingShingle | Ying Xiong Yu Si Yisi Feng Shipei Zhuo Bozhen Cui Zhigang Zhang Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma Immunity, Inflammation and Disease HNSCC lipid metabolism PI TCGA |
| title | Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma |
| title_full | Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma |
| title_fullStr | Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma |
| title_full_unstemmed | Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma |
| title_short | Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma |
| title_sort | prognostic value of lipid metabolism related genes in head and neck squamous cell carcinoma |
| topic | HNSCC lipid metabolism PI TCGA |
| url | https://doi.org/10.1002/iid3.379 |
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