Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
Abstract The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, imp...
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Nature Portfolio
2025-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07314-y |
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| author | José Luis Cabrera-Alarcon Raquel Cruz Marina Rosa-Moreno Ana Latorre-Pellicer Silvia Diz de Almeida Scourge Cohort Group José A. Riancho Augusto Rojas-Martinez Carlos Flores Pablo Lapunzina Fátima Sánchez-Cabo Ángel Carracedo José Antonio Enriquez |
| author_facet | José Luis Cabrera-Alarcon Raquel Cruz Marina Rosa-Moreno Ana Latorre-Pellicer Silvia Diz de Almeida Scourge Cohort Group José A. Riancho Augusto Rojas-Martinez Carlos Flores Pablo Lapunzina Fátima Sánchez-Cabo Ángel Carracedo José Antonio Enriquez |
| author_sort | José Luis Cabrera-Alarcon |
| collection | DOAJ |
| description | Abstract The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics. |
| format | Article |
| id | doaj-art-f678158976b24325b6137402fb7a0804 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-f678158976b24325b6137402fb7a08042025-01-12T12:35:33ZengNature PortfolioCommunications Biology2399-36422025-01-018111210.1038/s42003-024-07314-yShaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severityJosé Luis Cabrera-Alarcon0Raquel Cruz1Marina Rosa-Moreno2Ana Latorre-Pellicer3Silvia Diz de Almeida4Scourge Cohort GroupJosé A. Riancho5Augusto Rojas-Martinez6Carlos Flores7Pablo Lapunzina8Fátima Sánchez-Cabo9Ángel Carracedo10José Antonio Enriquez11Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Instituto de Salud Carlos IIICentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Grupo de Genética Clínica y Genómica Funcional, Facultad de Medicina, Universidad de Zaragoza, IIS Aragón, CIBERER-GCV02Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable.(CIBERFES) Instituto de Salud Carlos IIITecnológico de Monterrey, Escuela de Medicina y Ciencias de la SaludCentre for Biomedical Network Research on Respiratory Diseases (CIBERES), Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Instituto de Salud Carlos IIICentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Instituto de Salud Carlos IIICentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Abstract The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.https://doi.org/10.1038/s42003-024-07314-y |
| spellingShingle | José Luis Cabrera-Alarcon Raquel Cruz Marina Rosa-Moreno Ana Latorre-Pellicer Silvia Diz de Almeida Scourge Cohort Group José A. Riancho Augusto Rojas-Martinez Carlos Flores Pablo Lapunzina Fátima Sánchez-Cabo Ángel Carracedo José Antonio Enriquez Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity Communications Biology |
| title | Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity |
| title_full | Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity |
| title_fullStr | Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity |
| title_full_unstemmed | Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity |
| title_short | Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity |
| title_sort | shaping current european mitochondrial haplogroup frequency in response to infection the case of sars cov 2 severity |
| url | https://doi.org/10.1038/s42003-024-07314-y |
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