Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis
Abstract Background The use of lipid-lowering drugs in the dialysis population has been controversial and there is no target for the dialysis population. Objectives To elucidate the dose-response relationship between lipids and all-cause mortality in the dialysis population. Methods Computer searche...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12882-025-03981-z |
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| author | Ye Yao Jing Xiong Mi-Yuan Wang |
| author_facet | Ye Yao Jing Xiong Mi-Yuan Wang |
| author_sort | Ye Yao |
| collection | DOAJ |
| description | Abstract Background The use of lipid-lowering drugs in the dialysis population has been controversial and there is no target for the dialysis population. Objectives To elucidate the dose-response relationship between lipids and all-cause mortality in the dialysis population. Methods Computer searches of PubMed, Embase, Web of Science, CNKI, and Wanfang. Data were conducted to collect published cohort studies on lipids and all-cause mortality in the dialysis population from home and abroad up to February 2023. Meta-analysis was applied to calculate the combined effect size (Hazard ratio) and its 95% confidence interval and dose-response relationship by applying Stata17.0. Results A total of 11 publications with a cumulative total of 106,808 individuals were included. All-cause mortality was statistically different between the highest dose total cholesterol (TC) group and the low TC group (HR = 0.82, 95% CI = 0.75–0.90, P < 0.05). The TC range for lower all-cause mortality is > 140.5 mg/dL, and on this basis, TC in the range of 180–220 mg/dL may have a better prognosis for dialysis population. There was a nonlinear relationship between Non-high-density lipoprotein cholesterol (NHDL-C) cholesterol and all-cause mortality, with no statistical difference between the high and low dose group. In contrast, Low-density lipoprotein cholesterol (LDL-C) masked its association with all-cause mortality due to changes in death spectrum, differences in relative time risks, and other factors. In the 50–450 mg/dL range, all-cause mortality in the dialysis population was positively associated with triglycerides (TG), with a 2.5% increase in all-cause mortality per 50 mg/dL increase in TG (HR = 1.025, 95% CI = 1.003–1.048, P = 0.01). Conclusion TC is a target for monitoring the dialysis population, which has the lowest all-cause mortality in the range of 180–220 mg/dL. However, NHDL-C and LDL-C monitoring is not clinically meaningful. Increased TG can contribute to the risk of higher all-cause mortality in dialysis patients. |
| format | Article |
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| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Nephrology |
| spelling | doaj-art-f66dac62b8ac46a894814ec471483ea12025-02-09T12:16:54ZengBMCBMC Nephrology1471-23692025-02-0126111410.1186/s12882-025-03981-zDose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysisYe Yao0Jing Xiong1Mi-Yuan Wang2Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologySchool of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background The use of lipid-lowering drugs in the dialysis population has been controversial and there is no target for the dialysis population. Objectives To elucidate the dose-response relationship between lipids and all-cause mortality in the dialysis population. Methods Computer searches of PubMed, Embase, Web of Science, CNKI, and Wanfang. Data were conducted to collect published cohort studies on lipids and all-cause mortality in the dialysis population from home and abroad up to February 2023. Meta-analysis was applied to calculate the combined effect size (Hazard ratio) and its 95% confidence interval and dose-response relationship by applying Stata17.0. Results A total of 11 publications with a cumulative total of 106,808 individuals were included. All-cause mortality was statistically different between the highest dose total cholesterol (TC) group and the low TC group (HR = 0.82, 95% CI = 0.75–0.90, P < 0.05). The TC range for lower all-cause mortality is > 140.5 mg/dL, and on this basis, TC in the range of 180–220 mg/dL may have a better prognosis for dialysis population. There was a nonlinear relationship between Non-high-density lipoprotein cholesterol (NHDL-C) cholesterol and all-cause mortality, with no statistical difference between the high and low dose group. In contrast, Low-density lipoprotein cholesterol (LDL-C) masked its association with all-cause mortality due to changes in death spectrum, differences in relative time risks, and other factors. In the 50–450 mg/dL range, all-cause mortality in the dialysis population was positively associated with triglycerides (TG), with a 2.5% increase in all-cause mortality per 50 mg/dL increase in TG (HR = 1.025, 95% CI = 1.003–1.048, P = 0.01). Conclusion TC is a target for monitoring the dialysis population, which has the lowest all-cause mortality in the range of 180–220 mg/dL. However, NHDL-C and LDL-C monitoring is not clinically meaningful. Increased TG can contribute to the risk of higher all-cause mortality in dialysis patients.https://doi.org/10.1186/s12882-025-03981-zDose-response relationshipDialysisLipids |
| spellingShingle | Ye Yao Jing Xiong Mi-Yuan Wang Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis BMC Nephrology Dose-response relationship Dialysis Lipids |
| title | Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis |
| title_full | Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis |
| title_fullStr | Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis |
| title_full_unstemmed | Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis |
| title_short | Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis |
| title_sort | dose response relationship between lipids and all cause mortality in the dialysis population a meta analysis |
| topic | Dose-response relationship Dialysis Lipids |
| url | https://doi.org/10.1186/s12882-025-03981-z |
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