Association of blood pressure and left ventricular mass with subclinical coronary atherosclerosis
Background Left ventricular (LV) mass is closely associated with atherosclerotic heart disease, but the mechanisms are not well defined. This study aimed to evaluate the risk factors associated with LV mass and subclinical coronary atherosclerosis, in an Asian population free of baseline cardiovascu...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-02-01
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| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/12/1/e002791.full |
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| author | Weiting Huang Calvin Chin Rehena Sultana Chirk Jenn Ng Jonathan Jiunn Liang Yap Enver De Wei Loh Swee Yaw Tan Siew Ching Kong Khung K Yeo |
| author_facet | Weiting Huang Calvin Chin Rehena Sultana Chirk Jenn Ng Jonathan Jiunn Liang Yap Enver De Wei Loh Swee Yaw Tan Siew Ching Kong Khung K Yeo |
| author_sort | Weiting Huang |
| collection | DOAJ |
| description | Background Left ventricular (LV) mass is closely associated with atherosclerotic heart disease, but the mechanisms are not well defined. This study aimed to evaluate the risk factors associated with LV mass and subclinical coronary atherosclerosis, in an Asian population free of baseline cardiovascular disease.Methods The SingHEART study is a population-based cohort in which individuals underwent ambulatory blood pressure (BP) monitoring, cardiac MRI to measure indexed LV mass index (LVMI) and coronary artery calcium (CAC) scoring. Individuals were stratified based on LVMI and the presence of CAC, and intergroup differences in risk factors were analysed. Logistic regression models were used to assess the interaction of BP and LVMI on prevalent CAC.Results The study included 880 subjects (mean age 45.8±11.7 years, 51.4% women). Individuals with high LVMI had higher BP than those with normal LVMI. Across all LVMI groups, higher BP was associated with the presence of CAC. Compared with individuals with normotensive BP and normal LVMI, those with normotensive BP and high LVMI had no increased risk of prevalent CAC (p=0.530); however, risk was progressively higher in those with hypertensive BP and normal LVMI (risk ratio (RR) 1.47, 95% CI 1.13 to 1.91), or hypertensive BP and high LVMI (RR 1.72, 95% CI 1.26 to 2.36).Conclusions In this healthy asymptomatic population, hypertension was the strongest risk factor for high LVMI and prevalent CAC. LV hypertrophy was a risk modifier, and its prognostic significance in adults without hypertension requires further study. |
| format | Article |
| id | doaj-art-f664f55565e5468ea9277712e82d6891 |
| institution | Kabale University |
| issn | 2053-3624 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj-art-f664f55565e5468ea9277712e82d68912025-02-12T05:55:09ZengBMJ Publishing GroupOpen Heart2053-36242025-02-0112110.1136/openhrt-2024-002791Association of blood pressure and left ventricular mass with subclinical coronary atherosclerosisWeiting Huang0Calvin Chin1Rehena Sultana2Chirk Jenn Ng3Jonathan Jiunn Liang Yap4Enver De Wei Loh5Swee Yaw Tan6Siew Ching Kong7Khung K Yeo8Cardiology, National Heart Centre Singapore, SingaporeNational Heart Centre Singapore, SingaporeDuke-NUS Medical School, SingaporeDepartment of Research, SingHealth Polyclinics, SingaporeNational Heart Centre Singapore, SingaporeLee Kong Chian School of Medicine, SingaporeNational Heart Centre Singapore, SingaporeNational Heart Centre Singapore, SingaporeCardiology, National Heart Centre Singapore, SingaporeBackground Left ventricular (LV) mass is closely associated with atherosclerotic heart disease, but the mechanisms are not well defined. This study aimed to evaluate the risk factors associated with LV mass and subclinical coronary atherosclerosis, in an Asian population free of baseline cardiovascular disease.Methods The SingHEART study is a population-based cohort in which individuals underwent ambulatory blood pressure (BP) monitoring, cardiac MRI to measure indexed LV mass index (LVMI) and coronary artery calcium (CAC) scoring. Individuals were stratified based on LVMI and the presence of CAC, and intergroup differences in risk factors were analysed. Logistic regression models were used to assess the interaction of BP and LVMI on prevalent CAC.Results The study included 880 subjects (mean age 45.8±11.7 years, 51.4% women). Individuals with high LVMI had higher BP than those with normal LVMI. Across all LVMI groups, higher BP was associated with the presence of CAC. Compared with individuals with normotensive BP and normal LVMI, those with normotensive BP and high LVMI had no increased risk of prevalent CAC (p=0.530); however, risk was progressively higher in those with hypertensive BP and normal LVMI (risk ratio (RR) 1.47, 95% CI 1.13 to 1.91), or hypertensive BP and high LVMI (RR 1.72, 95% CI 1.26 to 2.36).Conclusions In this healthy asymptomatic population, hypertension was the strongest risk factor for high LVMI and prevalent CAC. LV hypertrophy was a risk modifier, and its prognostic significance in adults without hypertension requires further study.https://openheart.bmj.com/content/12/1/e002791.full |
| spellingShingle | Weiting Huang Calvin Chin Rehena Sultana Chirk Jenn Ng Jonathan Jiunn Liang Yap Enver De Wei Loh Swee Yaw Tan Siew Ching Kong Khung K Yeo Association of blood pressure and left ventricular mass with subclinical coronary atherosclerosis Open Heart |
| title | Association of blood pressure and left ventricular mass with subclinical coronary atherosclerosis |
| title_full | Association of blood pressure and left ventricular mass with subclinical coronary atherosclerosis |
| title_fullStr | Association of blood pressure and left ventricular mass with subclinical coronary atherosclerosis |
| title_full_unstemmed | Association of blood pressure and left ventricular mass with subclinical coronary atherosclerosis |
| title_short | Association of blood pressure and left ventricular mass with subclinical coronary atherosclerosis |
| title_sort | association of blood pressure and left ventricular mass with subclinical coronary atherosclerosis |
| url | https://openheart.bmj.com/content/12/1/e002791.full |
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