Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor
Factor V deficiency secondary to inhibitors is extremely rare and can be caused by a wide collection of exposures such as bovine thrombin and beta lactamase antibiotics. The management of factor V deficiency with inhibitor is a condition treated based on case reports due to the rarity of this condit...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/603402 |
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| _version_ | 1832550248808972288 |
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| author | Elizabeth S. John Minesh D. Patel Julio Hajdenberg |
| author_facet | Elizabeth S. John Minesh D. Patel Julio Hajdenberg |
| author_sort | Elizabeth S. John |
| collection | DOAJ |
| description | Factor V deficiency secondary to inhibitors is extremely rare and can be caused by a wide collection of exposures such as bovine thrombin and beta lactamase antibiotics. The management of factor V deficiency with inhibitor is a condition treated based on case reports due to the rarity of this condition. We describe a complicated case of an elderly patient with severe factor V deficiency with high inhibitor titer refractory to FEIBA (anti-inhibitor coagulation complex) treated with NovoSeven concurrently with cyclosporine immunosuppression and Rituxan. Given that there are no consensus guidelines on treatment, this case offers important insight into the therapeutic approaches that can be used to treat such patients. |
| format | Article |
| id | doaj-art-f6649cbd76d646ec96435fe57fed6664 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-f6649cbd76d646ec96435fe57fed66642025-02-03T06:07:27ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/603402603402Refractory Epistaxis due to Severe Factor V Deficiency with InhibitorElizabeth S. John0Minesh D. Patel1Julio Hajdenberg2Department of Medicine, Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08901, USADivision of Hematology and Oncology, University of Florida Health Cancer Center in Orlando, 1400 S Orange Avenue, MP700, Orlando, FL 32806, USADivision of Hematology and Oncology, University of Florida Health Cancer Center in Orlando, 1400 S Orange Avenue, MP700, Orlando, FL 32806, USAFactor V deficiency secondary to inhibitors is extremely rare and can be caused by a wide collection of exposures such as bovine thrombin and beta lactamase antibiotics. The management of factor V deficiency with inhibitor is a condition treated based on case reports due to the rarity of this condition. We describe a complicated case of an elderly patient with severe factor V deficiency with high inhibitor titer refractory to FEIBA (anti-inhibitor coagulation complex) treated with NovoSeven concurrently with cyclosporine immunosuppression and Rituxan. Given that there are no consensus guidelines on treatment, this case offers important insight into the therapeutic approaches that can be used to treat such patients.http://dx.doi.org/10.1155/2015/603402 |
| spellingShingle | Elizabeth S. John Minesh D. Patel Julio Hajdenberg Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor Case Reports in Hematology |
| title | Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor |
| title_full | Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor |
| title_fullStr | Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor |
| title_full_unstemmed | Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor |
| title_short | Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor |
| title_sort | refractory epistaxis due to severe factor v deficiency with inhibitor |
| url | http://dx.doi.org/10.1155/2015/603402 |
| work_keys_str_mv | AT elizabethsjohn refractoryepistaxisduetoseverefactorvdeficiencywithinhibitor AT mineshdpatel refractoryepistaxisduetoseverefactorvdeficiencywithinhibitor AT juliohajdenberg refractoryepistaxisduetoseverefactorvdeficiencywithinhibitor |