Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice
Abstract Rice is an excellent source of protein, and has an adequate balance of amino acids with the exception of the essential amino acid lysine. By using a combined enhancement of lysine synthesis and suppression of its catabolism, we had produced two transgenic rice lines HFL1 and HFL2 (High Free...
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| Format: | Article |
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Nature Portfolio
2017-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-01555-0 |
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| author | Qing-Qing Yang Pui Kit Suen Chang-Quan Zhang Wan Sheung Mak Ming-Hong Gu Qiao-Quan Liu Samuel Sai-Ming Sun |
| author_facet | Qing-Qing Yang Pui Kit Suen Chang-Quan Zhang Wan Sheung Mak Ming-Hong Gu Qiao-Quan Liu Samuel Sai-Ming Sun |
| author_sort | Qing-Qing Yang |
| collection | DOAJ |
| description | Abstract Rice is an excellent source of protein, and has an adequate balance of amino acids with the exception of the essential amino acid lysine. By using a combined enhancement of lysine synthesis and suppression of its catabolism, we had produced two transgenic rice lines HFL1 and HFL2 (High Free Lysine) containing high concentration of free lysine. In this study, a 70-day rat feeding study was conducted to assess the nutritional value of two transgenic lines as compared with either their wild type (WT) or the WT rice supplemented with different concentrations of L-lysine. The results revealed that animal performance, including body weight, food intake, and food efficiency, was greater in the HFL groups than in the WT group. Moreover, the HFL diets had increased protein apparent digestibility, protein efficiency ratio, and lysine availability than the WT diet. Based on the linear relationship between dietary L-lysine concentrations and animal performance, it indicated that the biological indexes of the HFL groups were similar or better than that of the WT20 group, which was supplemented with L-lysine concentrations similar to those present in the HFL diets. Therefore, lysine-biofortified rice contributed to improved growth performance, food efficiency, and lysine availability in growing rats. |
| format | Article |
| id | doaj-art-f6633d586b764a98b20e6e2303dd6b69 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f6633d586b764a98b20e6e2303dd6b692025-02-09T12:38:30ZengNature PortfolioScientific Reports2045-23222017-05-017111110.1038/s41598-017-01555-0Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified riceQing-Qing Yang0Pui Kit Suen1Chang-Quan Zhang2Wan Sheung Mak3Ming-Hong Gu4Qiao-Quan Liu5Samuel Sai-Ming Sun6Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou UniversityState Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong KongKey Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou UniversityState Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong KongKey Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou UniversityKey Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou UniversityState Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong KongAbstract Rice is an excellent source of protein, and has an adequate balance of amino acids with the exception of the essential amino acid lysine. By using a combined enhancement of lysine synthesis and suppression of its catabolism, we had produced two transgenic rice lines HFL1 and HFL2 (High Free Lysine) containing high concentration of free lysine. In this study, a 70-day rat feeding study was conducted to assess the nutritional value of two transgenic lines as compared with either their wild type (WT) or the WT rice supplemented with different concentrations of L-lysine. The results revealed that animal performance, including body weight, food intake, and food efficiency, was greater in the HFL groups than in the WT group. Moreover, the HFL diets had increased protein apparent digestibility, protein efficiency ratio, and lysine availability than the WT diet. Based on the linear relationship between dietary L-lysine concentrations and animal performance, it indicated that the biological indexes of the HFL groups were similar or better than that of the WT20 group, which was supplemented with L-lysine concentrations similar to those present in the HFL diets. Therefore, lysine-biofortified rice contributed to improved growth performance, food efficiency, and lysine availability in growing rats.https://doi.org/10.1038/s41598-017-01555-0 |
| spellingShingle | Qing-Qing Yang Pui Kit Suen Chang-Quan Zhang Wan Sheung Mak Ming-Hong Gu Qiao-Quan Liu Samuel Sai-Ming Sun Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice Scientific Reports |
| title | Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice |
| title_full | Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice |
| title_fullStr | Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice |
| title_full_unstemmed | Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice |
| title_short | Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice |
| title_sort | improved growth performance food efficiency and lysine availability in growing rats fed with lysine biofortified rice |
| url | https://doi.org/10.1038/s41598-017-01555-0 |
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