Modeling treatment of diabetic wounds with oxygen therapy and senolytic drug
Abstract Diabetic wounds are common in patients with type 2 diabetes; they are ischemic and inflammatory, and difficult to heal without intervention. Hyperbaric oxygen therapy (HBOT) is a standard treatment, but its effectiveness is limited to a subset of the aging population. Senescent fibroblasts,...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-02852-9 |
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| Summary: | Abstract Diabetic wounds are common in patients with type 2 diabetes; they are ischemic and inflammatory, and difficult to heal without intervention. Hyperbaric oxygen therapy (HBOT) is a standard treatment, but its effectiveness is limited to a subset of the aging population. Senescent fibroblasts, a hallmark of aging, impair wound healing, and senolytic drugs, like quercetin (Q), which target senescent cells, may improve healing. In this study, we developed a mathematical model that defines biological aging through two parameters, $$\eta$$ and $$A_0$$ , that decline with age. These parameters reflect the biological age of an individual, where $$\eta$$ represents fibroblast proliferation and $$A_0$$ represents the production of the angiogenetic protein VEGF. Our model predicts that treatment with only HBOT achieves wound closure, within normal expectable time, for patients with a limited subset pairs of $$(\eta ,A_0)$$ , and this subset is increased to a larger subset by combining Q with HBOT. The two subsets of $$(\eta ,A_0)$$ are determined explicitly by simulations of the model. To make these results applicable in clinical setting, one will have to relate the aging parameters $$\eta$$ and $$A_0$$ to tangible marks of biological-aging factors. |
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| ISSN: | 2045-2322 |