Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an Adolescent
Background. Granulomatosis with polyangiitis disease (GPA) is a rare vasculitis characterized by granulomatous inflammation of respiratory tracts, glomerulonephritis, and vasculitis of other organs. Case Presentation. A 13-year-old girl was referred due to swelling and pain on her left arm. The Dopp...
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Wiley
2021-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2021/5520258 |
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| author | Mohsen Jari |
| author_facet | Mohsen Jari |
| author_sort | Mohsen Jari |
| collection | DOAJ |
| description | Background. Granulomatosis with polyangiitis disease (GPA) is a rare vasculitis characterized by granulomatous inflammation of respiratory tracts, glomerulonephritis, and vasculitis of other organs. Case Presentation. A 13-year-old girl was referred due to swelling and pain on her left arm. The Doppler and compression ultrasonography showed noncompressible left brachial and axillary vein thrombosis. Sinus computed tomography (CT) demonstrated pansinusitis, and spiral chest CT showed alveolar hemorrhage. Laboratory tests showed hematuria, proteinuria, and highly positive antineutrophil cytoplasmic antibody (cANCA). Laboratory tests of coagulopathy were normal. The patient was recognized as a case of GPA. Conclusion. Although GPA is not frequently associated with thrombosis especially in children, this is the first report that shows thrombosis may be the first manifestation of GPA in an adolescent. |
| format | Article |
| id | doaj-art-f652808f8de04fdb893e95fc47c9ce69 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-f652808f8de04fdb893e95fc47c9ce692025-02-03T00:58:55ZengWileyCase Reports in Hematology2090-65602090-65792021-01-01202110.1155/2021/55202585520258Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an AdolescentMohsen Jari0Department of Pediatric Rheumatology, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, IranBackground. Granulomatosis with polyangiitis disease (GPA) is a rare vasculitis characterized by granulomatous inflammation of respiratory tracts, glomerulonephritis, and vasculitis of other organs. Case Presentation. A 13-year-old girl was referred due to swelling and pain on her left arm. The Doppler and compression ultrasonography showed noncompressible left brachial and axillary vein thrombosis. Sinus computed tomography (CT) demonstrated pansinusitis, and spiral chest CT showed alveolar hemorrhage. Laboratory tests showed hematuria, proteinuria, and highly positive antineutrophil cytoplasmic antibody (cANCA). Laboratory tests of coagulopathy were normal. The patient was recognized as a case of GPA. Conclusion. Although GPA is not frequently associated with thrombosis especially in children, this is the first report that shows thrombosis may be the first manifestation of GPA in an adolescent.http://dx.doi.org/10.1155/2021/5520258 |
| spellingShingle | Mohsen Jari Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an Adolescent Case Reports in Hematology |
| title | Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an Adolescent |
| title_full | Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an Adolescent |
| title_fullStr | Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an Adolescent |
| title_full_unstemmed | Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an Adolescent |
| title_short | Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an Adolescent |
| title_sort | thrombosis as the first manifestation of granulomatosis with polyangiitis disease in an adolescent |
| url | http://dx.doi.org/10.1155/2021/5520258 |
| work_keys_str_mv | AT mohsenjari thrombosisasthefirstmanifestationofgranulomatosiswithpolyangiitisdiseaseinanadolescent |