Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and LC-OCT evaluation
Skin aging is characterized by loss of elasticity, wrinkles, and textural changes. Treatments range from non-invasive options, such as alpha-hydroxy acids and retinoic acid, to invasive procedures like chemical peels and laser therapies. Plasma radiofrequency (PRF) offers a minimally invasive solut...
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PAGEPress Publications
2025-04-01
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| Series: | Dermatology Reports |
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| Online Access: | https://www.pagepress.org/journals/dr/article/view/10342 |
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| author | Caterina Mariarosaria Giorgio Gaetano Licata Eugenia Veronica Di Brizzi Graziella Babino Elisabetta Fulgione Elvira Moscarella Giuseppe Lodi Nicola Maria Giorgio Vittorio Tancredi Giuseppe Argenziano Adone Baroni |
| author_facet | Caterina Mariarosaria Giorgio Gaetano Licata Eugenia Veronica Di Brizzi Graziella Babino Elisabetta Fulgione Elvira Moscarella Giuseppe Lodi Nicola Maria Giorgio Vittorio Tancredi Giuseppe Argenziano Adone Baroni |
| author_sort | Caterina Mariarosaria Giorgio |
| collection | DOAJ |
| description |
Skin aging is characterized by loss of elasticity, wrinkles, and textural changes. Treatments range from non-invasive options, such as alpha-hydroxy acids and retinoic acid, to invasive procedures like chemical peels and laser therapies. Plasma radiofrequency (PRF) offers a minimally invasive solution with a favorable balance of efficacy and tolerability. This study assessed the clinical and microscopic outcomes of combining PRF ablation with a galenic cream containing 5% resorcinol in Nourivan™ Antiox for facial skin aging. Forty-one patients with visible signs of aging underwent a single PRF session followed by weekly applications of a 5% resorcinol cream for six weeks. Outcomes were evaluated using digital photography and line-field confocal optical coherence tomography (LC-OCT) at baseline, three months, and six months. Primary endpoints included wrinkle reduction and texture improvement; secondary endpoints included adverse effects and patient satisfaction. At six months, 92% of patients showed significant wrinkle reduction and improved collagen organization in LC-OCT images. Skin texture improvements were reported by 85% of patients. Adverse effects, such as mild erythema and peeling, were transient and resolved without discontinuation. PRF ablation combined with 5% resorcinol cream is an effective and well-tolerated treatment for facial skin aging, offering significant improvements in skin texture and appearance. Further research is needed to confirm these findings and explore long-term effects.
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| format | Article |
| id | doaj-art-f650bcd9a5214be5862829da40405f39 |
| institution | DOAJ |
| issn | 2036-7392 2036-7406 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj-art-f650bcd9a5214be5862829da40405f392025-08-20T03:03:21ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062025-04-0110.4081/dr.2025.10342Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and LC-OCT evaluationCaterina Mariarosaria Giorgio0Gaetano Licata1Eugenia Veronica Di Brizzi2Graziella Babino3Elisabetta Fulgione4Elvira Moscarella5Giuseppe Lodi6Nicola Maria Giorgio7Vittorio Tancredi8Giuseppe Argenziano9Adone Baroni10Dermatology Unit, University of Campania, NaplesDermatology Unit, San Antonio Abate Hospital, TrapaniDermatology Unit, University of Campania, NaplesDermatology Unit, Department of Health Sciences, University of Basilicata, PotenzaDermatology Unit, University of Campania, NaplesDermatology Unit, University of Campania, NaplesDermatology Unit, University of Campania, NaplesDermatology Unit, University of Campania, NaplesDermatology Unit, University of Campania, NaplesDermatology Unit, University of Campania, NaplesDermatology Unit, University of Campania, Naples Skin aging is characterized by loss of elasticity, wrinkles, and textural changes. Treatments range from non-invasive options, such as alpha-hydroxy acids and retinoic acid, to invasive procedures like chemical peels and laser therapies. Plasma radiofrequency (PRF) offers a minimally invasive solution with a favorable balance of efficacy and tolerability. This study assessed the clinical and microscopic outcomes of combining PRF ablation with a galenic cream containing 5% resorcinol in Nourivan™ Antiox for facial skin aging. Forty-one patients with visible signs of aging underwent a single PRF session followed by weekly applications of a 5% resorcinol cream for six weeks. Outcomes were evaluated using digital photography and line-field confocal optical coherence tomography (LC-OCT) at baseline, three months, and six months. Primary endpoints included wrinkle reduction and texture improvement; secondary endpoints included adverse effects and patient satisfaction. At six months, 92% of patients showed significant wrinkle reduction and improved collagen organization in LC-OCT images. Skin texture improvements were reported by 85% of patients. Adverse effects, such as mild erythema and peeling, were transient and resolved without discontinuation. PRF ablation combined with 5% resorcinol cream is an effective and well-tolerated treatment for facial skin aging, offering significant improvements in skin texture and appearance. Further research is needed to confirm these findings and explore long-term effects. https://www.pagepress.org/journals/dr/article/view/10342Facial skin rejuvenationPlasma radiofrequencyresorcinolLC-OCTaesthetic dermatology |
| spellingShingle | Caterina Mariarosaria Giorgio Gaetano Licata Eugenia Veronica Di Brizzi Graziella Babino Elisabetta Fulgione Elvira Moscarella Giuseppe Lodi Nicola Maria Giorgio Vittorio Tancredi Giuseppe Argenziano Adone Baroni Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and LC-OCT evaluation Dermatology Reports Facial skin rejuvenation Plasma radiofrequency resorcinol LC-OCT aesthetic dermatology |
| title | Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and LC-OCT evaluation |
| title_full | Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and LC-OCT evaluation |
| title_fullStr | Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and LC-OCT evaluation |
| title_full_unstemmed | Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and LC-OCT evaluation |
| title_short | Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and LC-OCT evaluation |
| title_sort | facial skin rejuvenation through plasma radiofrequency ablation combined with 5 resorcinol cream clinical and lc oct evaluation |
| topic | Facial skin rejuvenation Plasma radiofrequency resorcinol LC-OCT aesthetic dermatology |
| url | https://www.pagepress.org/journals/dr/article/view/10342 |
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