Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of Pathogenesis
Hypophysitis is a rare inflammatory condition of the pituitary gland that has three main histologic subtypes: lymphocytic hypophysitis (LH), granulomatous hypophysitis (GH), and xanthomatous hypophysitis (XH). Among these, LH is the most common and is strongly associated with the postpartum state, w...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/7510323 |
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| author | Upasana Joneja D. Craig Hooper James J. Evans Mark T. Curtis |
| author_facet | Upasana Joneja D. Craig Hooper James J. Evans Mark T. Curtis |
| author_sort | Upasana Joneja |
| collection | DOAJ |
| description | Hypophysitis is a rare inflammatory condition of the pituitary gland that has three main histologic subtypes: lymphocytic hypophysitis (LH), granulomatous hypophysitis (GH), and xanthomatous hypophysitis (XH). Among these, LH is the most common and is strongly associated with the postpartum state, while XH is the least common. Many hypophysitis cases have been reported in the literature but only a few cases of postpartum GH have been discussed. Here, we describe a case of GH in a 24-year-old female presenting eleven days postpartum. We also review the current literature on postpartum GH and discuss the possible alterations in the immune environment during and after pregnancy that could explain this phenomenon. With more cases of GH being reported, the commonalities of female predominance, postpartum time of presentation, and occasional spontaneous resolution between LH and GH lend support to the theory that these two diseases likely represent spectrums of a single immunologic disorder. |
| format | Article |
| id | doaj-art-f645c7381c63442c881dcac3728b3fc1 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-f645c7381c63442c881dcac3728b3fc12025-02-03T05:58:37ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/75103237510323Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of PathogenesisUpasana Joneja0D. Craig Hooper1James J. Evans2Mark T. Curtis3Department of Pathology, Cell Biology and Anatomy, Thomas Jefferson University Hospitals, Philadelphia, PA, USADepartment of Cancer Biology, Thomas Jefferson University Hospitals, Philadelphia, PA, USADepartment of Neurosurgery, Thomas Jefferson University Hospitals, Philadelphia, PA, USADepartment of Pathology, Cell Biology and Anatomy, Thomas Jefferson University Hospitals, Philadelphia, PA, USAHypophysitis is a rare inflammatory condition of the pituitary gland that has three main histologic subtypes: lymphocytic hypophysitis (LH), granulomatous hypophysitis (GH), and xanthomatous hypophysitis (XH). Among these, LH is the most common and is strongly associated with the postpartum state, while XH is the least common. Many hypophysitis cases have been reported in the literature but only a few cases of postpartum GH have been discussed. Here, we describe a case of GH in a 24-year-old female presenting eleven days postpartum. We also review the current literature on postpartum GH and discuss the possible alterations in the immune environment during and after pregnancy that could explain this phenomenon. With more cases of GH being reported, the commonalities of female predominance, postpartum time of presentation, and occasional spontaneous resolution between LH and GH lend support to the theory that these two diseases likely represent spectrums of a single immunologic disorder.http://dx.doi.org/10.1155/2016/7510323 |
| spellingShingle | Upasana Joneja D. Craig Hooper James J. Evans Mark T. Curtis Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of Pathogenesis Case Reports in Pathology |
| title | Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of Pathogenesis |
| title_full | Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of Pathogenesis |
| title_fullStr | Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of Pathogenesis |
| title_full_unstemmed | Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of Pathogenesis |
| title_short | Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of Pathogenesis |
| title_sort | postpartum granulomatous hypophysitis a case study review of the literature and discussion of pathogenesis |
| url | http://dx.doi.org/10.1155/2016/7510323 |
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