Apoptotic Pathways in Pemphigus
Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mecha...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/456841 |
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| _version_ | 1832562437557059584 |
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| author | Meryem Bektas Puneet Jolly David S. Rubenstein |
| author_facet | Meryem Bektas Puneet Jolly David S. Rubenstein |
| author_sort | Meryem Bektas |
| collection | DOAJ |
| description | Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis. We review the current literature examining the role of apoptosis in pemphigus. Current data suggest that apoptosis is not required for blister induction, but that activation of proapoptotic proteins, including caspase cysteine proteinases, may sensitize cells to the acantholytic effects of pemphigus IgG. |
| format | Article |
| id | doaj-art-f6318ce15e4c404f8ef21d70da5eec2e |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-f6318ce15e4c404f8ef21d70da5eec2e2025-02-03T01:22:37ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/456841456841Apoptotic Pathways in PemphigusMeryem Bektas0Puneet Jolly1David S. Rubenstein2Department of Dermatology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USADepartment of Dermatology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USADepartment of Dermatology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USAPemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis. We review the current literature examining the role of apoptosis in pemphigus. Current data suggest that apoptosis is not required for blister induction, but that activation of proapoptotic proteins, including caspase cysteine proteinases, may sensitize cells to the acantholytic effects of pemphigus IgG.http://dx.doi.org/10.1155/2010/456841 |
| spellingShingle | Meryem Bektas Puneet Jolly David S. Rubenstein Apoptotic Pathways in Pemphigus Dermatology Research and Practice |
| title | Apoptotic Pathways in Pemphigus |
| title_full | Apoptotic Pathways in Pemphigus |
| title_fullStr | Apoptotic Pathways in Pemphigus |
| title_full_unstemmed | Apoptotic Pathways in Pemphigus |
| title_short | Apoptotic Pathways in Pemphigus |
| title_sort | apoptotic pathways in pemphigus |
| url | http://dx.doi.org/10.1155/2010/456841 |
| work_keys_str_mv | AT meryembektas apoptoticpathwaysinpemphigus AT puneetjolly apoptoticpathwaysinpemphigus AT davidsrubenstein apoptoticpathwaysinpemphigus |