Apoptotic Pathways in Pemphigus

Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mecha...

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Main Authors: Meryem Bektas, Puneet Jolly, David S. Rubenstein
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Dermatology Research and Practice
Online Access:http://dx.doi.org/10.1155/2010/456841
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author Meryem Bektas
Puneet Jolly
David S. Rubenstein
author_facet Meryem Bektas
Puneet Jolly
David S. Rubenstein
author_sort Meryem Bektas
collection DOAJ
description Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis. We review the current literature examining the role of apoptosis in pemphigus. Current data suggest that apoptosis is not required for blister induction, but that activation of proapoptotic proteins, including caspase cysteine proteinases, may sensitize cells to the acantholytic effects of pemphigus IgG.
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spelling doaj-art-f6318ce15e4c404f8ef21d70da5eec2e2025-02-03T01:22:37ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/456841456841Apoptotic Pathways in PemphigusMeryem Bektas0Puneet Jolly1David S. Rubenstein2Department of Dermatology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USADepartment of Dermatology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USADepartment of Dermatology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USAPemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis. We review the current literature examining the role of apoptosis in pemphigus. Current data suggest that apoptosis is not required for blister induction, but that activation of proapoptotic proteins, including caspase cysteine proteinases, may sensitize cells to the acantholytic effects of pemphigus IgG.http://dx.doi.org/10.1155/2010/456841
spellingShingle Meryem Bektas
Puneet Jolly
David S. Rubenstein
Apoptotic Pathways in Pemphigus
Dermatology Research and Practice
title Apoptotic Pathways in Pemphigus
title_full Apoptotic Pathways in Pemphigus
title_fullStr Apoptotic Pathways in Pemphigus
title_full_unstemmed Apoptotic Pathways in Pemphigus
title_short Apoptotic Pathways in Pemphigus
title_sort apoptotic pathways in pemphigus
url http://dx.doi.org/10.1155/2010/456841
work_keys_str_mv AT meryembektas apoptoticpathwaysinpemphigus
AT puneetjolly apoptoticpathwaysinpemphigus
AT davidsrubenstein apoptoticpathwaysinpemphigus