Luteolin Alleviates Inflammation Induced by <i>Staphylococcus aureus</i> in Bovine Mammary Epithelial Cells by Attenuating NF-κB and MAPK Activation

Luteolin Alleviates Inflammation Induced by <i>Staphylococcus aureus</i> in Bovine Mammary Epithelial Cells by Attenuating NF-κB and MAPK Activation

The internalization of <i>S. aureus</i> in bMECs is a major pathogenic mechanism leading to mastitis, causing significant economic losses in the dairy industry. Numerous plants contain Lut, a natural flavonoid with anti-inflammatory and antioxidant properties. However, little is known ab...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yingfang Guo, Jinxin Zhang, Ting Yuan, Cheng Yang, Qingqing Zhou, Aftab Shaukat, Ganzhen Deng, Xiaoyan Wang
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Veterinary Sciences
Subjects:	luteolin <i>Staphylococcus aureus</i> TLR2 NF-κB pathway MAPK pathway mammary epithelial cells
Online Access:	https://www.mdpi.com/2306-7381/12/2/96
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

<i>Triglochin maritima</i> Extracts Exert Anti-Melanogenic Properties via the CREB/MAPK Pathway in B16F10 Cells
by: Won-Hwi Lee, et al.
Published: (2024-11-01)

Luteolin-Rich Extract from <i>Harrisonia perforata</i> (Blanco) Merr. Root Alleviates SARS-CoV-2 Spike Protein-Stimulated Lung Inflammation via Inhibition of MAPK/NLRP3 Inflammasome Signaling Pathways
by: Warathit Semmarath, et al.
Published: (2025-07-01)

Oxypeucedanin hydrate alleviates rheumatoid arthritis by inhibiting the TLR4-MD2/NF-κB/MAPK signaling axis
by: Liu Mengdan, et al.
Published: (2024-05-01)

Roles of MAPK and Nrf2 signaling pathways in quercetin alleviating redox imbalance induced by hydrogen peroxide in mammary epithelial cells
by: Yongxin Li, et al.
Published: (2024-01-01)

Protective effect of saikosaponin D against gestational diabetes mellitus via regulating TLR4/MyD88/NF-κB and MAPK signaling pathway
by: Lu-Lu Wang, et al.
Published: (2025-07-01)

Identification of Peptides from Edible <i>Pleurotus eryngii</i> Mushroom Feet and the Effect of Delaying D-Galactose-Induced Senescence of PC12 Cells Through TLR4/NF-κB/MAPK Signaling Pathways
by: Fen Zhao, et al.
Published: (2024-11-01)

Luteolin suppresses inflammation and oxidative stress in chronic obstructive pulmonary disease through inhibition of the NOX4‐mediated NF‐κB signaling pathway
by: Mingfei Li, et al.
Published: (2023-04-01)

Immunoenhancement Function of the Novel Hexapeptide (LVVLGH) from Thick-Shelled Mussel (<i>Mytilus coruscus</i>) on Immunodeficient Mice by Activating the NF-κB/MAPK Pathway
by: Xu Yang, et al.
Published: (2025-05-01)

Luteolin 7-Glucuronide in <i>Artemisia rupestris</i> L. Extract Attenuates Pulmonary Fibrosis by Inhibiting Fibroblast Activation and FMT via Targeting of TGF-β1
by: Lingfeng Peng, et al.
Published: (2025-04-01)

Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages
by: Qi Wang, et al.
Published: (2022-05-01)

Identification of potential molecular targets of luteolin in the treatment of hepatocellular carcinoma based on network pharmacology and transcriptome sequencing technology
by: Yunqi Han, et al.
Published: (2025-08-01)

The Effect of <i>Semen Ziziphi Spinosae</i> Extract on the p38MAPK/NF-κB Signaling Pathway in Insomniac Rats
by: Mingyu Ji, et al.
Published: (2024-12-01)

Phenolics from <i>Ilex rotunda</i> Possess Antioxidative Effects and Block Activation of MAPK and NF-κB Signaling by Inhibiting IL-2 Production in CD3/CD28 Activated Jurkat T Cells
by: Ducdat Le, et al.
Published: (2025-02-01)

PD-1 suppression enhances HIV reactivation and T-cell immunity via MAPK/NF-κB signaling
by: Xueru Lin, et al.
Published: (2025-04-01)

Mechanism of rapamycin alleviating inflammatory response in bovine mammary epithelial cells
by: XU Lianbin, et al.
Published: (2022-04-01)

<i>Chlorella pyrenoidosa</i> Polysaccharide CPP-3a Promotes M1 Polarization of Macrophages via TLR4/2-MyD88-NF-κB/p38 MAPK Signaling Pathways
by: Yihua Pi, et al.
Published: (2025-07-01)

Comparative Study of Antiviral Activity of Luteolin and 7,3’-Disulfate Luteolin
by: N. V. Krylova, et al.
Published: (2020-05-01)

Syndecan-3 inhibits lipopolysaccharide-induced inflammation of bovine mammary epithelial cells through the NF-κB signal transduction pathway
by: Haibin Yu, et al.
Published: (2024-12-01)

Chartarlactams U-X: Novel Phenylspirodrimanes from a Marine Derived Fungus <i>Stachybotrys</i> sp. SZU-W23 with Anti-Inflammatory Activity Mediated by the NF-κB/ROS Signaling Pathways
by: Yanhua Wu, et al.
Published: (2025-05-01)

Tea Polyphenol Protects the Immune Barrier and Inhibits TLR2/NF-κB/MLCK Signal Activation to Prevent Inflammatory Injury in the Intestines of Common Carp (<i>Cyprinus carpio</i> L.)
by: Man Qian, et al.
Published: (2025-01-01)

LMAN2 Promotes Breast Cancer Tumorigenesis and Drug Resistance by Interacting With MAPK9 via Activation of the MAPK Pathway
by: Chen Feng, et al.
Published: (2024-12-01)

PxDorsal Regulates the Expression of Antimicrobial Peptides and Affects the Bt Susceptibility of <i>Plutella xylostella</i>
by: Yan Sun, et al.
Published: (2025-02-01)

Mechanism of Brucea javanica against multiple myeloma via TNF-NF-κB signaling
by: Yuan Wang, et al.
Published: (2025-07-01)

Effect of Chitooligosaccharides on TLR2/NF-κB Signaling in LPS-Stimulated RAW 264.7 Macrophages
by: Mengting Zhao, et al.
Published: (2025-05-01)

Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway
by: Yihui Zhai, et al.
Published: (2025-03-01)

Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-κB pathway
by: Ziqiang Dong, et al.
Published: (2025-03-01)

<i>Areca catechu</i> L. Extract Inhibits Colorectal Cancer Tumor Growth by Modulating Cell Apoptosis and Autophagy
by: Meng-Hsiu Tsai, et al.
Published: (2025-02-01)

Dihydrogeodin from <i>Fennellia flavipes</i> Modulates Platelet Aggregation via Downregulation of Calcium Signaling, αIIbβ<sub>3</sub> Integrins, MAPK, and PI3K/Akt Pathways
by: Abdul Wahab Akram, et al.
Published: (2025-05-01)

The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways
by: Chunxing Pan, et al.
Published: (2023-01-01)

Morroniside ameliorates sevoflurane anesthesia-induced cognitive dysfunction in aged mice through modulating the TLR4/NF-κB pathway
by: Jianxing Chen, et al.
Published: (2024-12-01)

Optimization of Extraction of Luteolin from <i>Schisandra chinensis</i> by Ionic Liquid–Enzyme Complex System and Antioxidant Study Analysis
by: Jingwei Hao, et al.
Published: (2024-12-01)

Salted egg white derived-peptides VF-4 and DR-8 improve DSS-induced colitis in mice by inhibiting NF-κB/MAPK/PI3K-AKT signaling pathways and modulating gut microbiota composition
by: Na Zhou, et al.
Published: (2025-06-01)

Dichloromethane Extract from <i>Amburana cearensis</i> (Allemão) A.C. Sm. Seeds and Its Coumarin Reduce ROS Production and Protect PC12 Cells Against Glutamate Excitotoxicity and Oxygen-Glucose Deprivation
by: Flávia Santos Sanches, et al.
Published: (2025-04-01)

Mechanistic Study on the Alleviation of Endometritis in Mice Through Inhibition of NF-κB and MAPK Signaling Pathways by Berberine and Carvacrol
by: Xiaoshan Liang, et al.
Published: (2025-04-01)

Dietary supplementation with farnesol confers a protective effect on the intestine of broiler chickens challenged with lipopolysaccharide by reshaping intestinal flora structure and regulating TLR4/NF-κB signaling pathway
by: Peng Li, et al.
Published: (2025-04-01)

Anti-Inflammatory Effects of <i>Apostichopus japonicus</i> Extract in <i>Porphyromonas gingivalis</i>-Stimulated RAW 264.7 Cells
by: Min-jeong Kim, et al.
Published: (2024-11-01)

Huangqi decoction improved the inflammatory response of rats with diabetic nephropathy by inhibiting TLR4/NF-κB signal pathway
by: Chi Yang-feng, et al.
Published: (2022-01-01)

Immunomodulatory Effects of Polysaccharides from <i>Porphyra haitanensis</i> in Hydrocortisone-Induced Immunocompromised Mice
by: Chunying Du, et al.
Published: (2025-03-01)

Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway
by: Shi Y, et al.
Published: (2025-01-01)

Music intervention mitigates LPS-induced gut barrier disruption and immune stress in broilers via TLR4/NF-κB regulation
by: Shengzi Jin, et al.
Published: (2025-07-01)