Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride
Background: The most advanced type of neurodegenerative disease, Alzheimer's disease (AD), significantly reduces cognitive performance. Oxidative stress plays a role in the pathophysiological pathways of several neurodegenerative illnesses. Aluminum is one of the most potent neurotoxins known t...
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Elsevier
2025-03-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459325000101 |
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| author | Reena Deshmukh Manisha Jaiswal Anshita Shukla Umesh Patil Mukesh Sharma |
| author_facet | Reena Deshmukh Manisha Jaiswal Anshita Shukla Umesh Patil Mukesh Sharma |
| author_sort | Reena Deshmukh |
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| description | Background: The most advanced type of neurodegenerative disease, Alzheimer's disease (AD), significantly reduces cognitive performance. Oxidative stress plays a role in the pathophysiological pathways of several neurodegenerative illnesses. Aluminum is one of the most potent neurotoxins known to cause oxidative stress in neurodegenerative disorders. Since there are currently few therapy options for AD, more alternatives are required. The current investigation aimed to assess the nootropic potential of Swertia chirata in rats. Materials and Method: AlCl3 (100 mg/kg, p.o.) was used to induce amnesia, piracetam (500 mg/kg, p.o.) was employed as a standard, and an ethanolic extract of Swertia chirata (50, 100, 200, 400 mg/kg) was utilized to assess nootropic activity. The Novel Object Recognition test and the elevated plus maze in AlCl3-induced amnesia models were used to evaluate the effects of medications on learning and memory in rats. This impairment is likely due to the increased vulnerability of brain cells to oxidative stress. Numerous studies have demonstrated that certain flavonoid antioxidants reduce oxidative stress-induced neuronal apoptosis. Results: Swertia chirata ethanolic extract exhibited longer exploration times for unfamiliar objects compared to familiar ones. Additionally, the ethanolic extract demonstrated a reduction in transfer latency in the elevated plus maze (EPM) in the AlCl3-induced amnesia paradigm, indicating an improvement in cognitive function. Conclusion: In experimental models, the ethanolic extract of Swertia chirata significantly (p < 0.05) reversed AlCl3-induced amnesia and improved learning and memory. The study demonstrated the neuroprotective qualities of the extract. Its anti-inflammatory and antioxidant properties may contribute to its potential in treating cognitive disorders, including dementia and Alzheimer's disease. |
| format | Article |
| id | doaj-art-f6102fff952e42dfafa4d0c462feab12 |
| institution | Kabale University |
| issn | 2666-4593 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-f6102fff952e42dfafa4d0c462feab122025-02-09T05:01:29ZengElsevierBrain Disorders2666-45932025-03-0117100190Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chlorideReena Deshmukh0Manisha Jaiswal1Anshita Shukla2Umesh Patil3Mukesh Sharma4Rungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, IndiaRungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, IndiaRungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, IndiaDepartment of Pharmaceutical Science. Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, M.P. 470003, IndiaRungta College of Pharmaceutical Sciences and Research, Bhilai 490024, Chhattisgarh, India; Corresponding author.Background: The most advanced type of neurodegenerative disease, Alzheimer's disease (AD), significantly reduces cognitive performance. Oxidative stress plays a role in the pathophysiological pathways of several neurodegenerative illnesses. Aluminum is one of the most potent neurotoxins known to cause oxidative stress in neurodegenerative disorders. Since there are currently few therapy options for AD, more alternatives are required. The current investigation aimed to assess the nootropic potential of Swertia chirata in rats. Materials and Method: AlCl3 (100 mg/kg, p.o.) was used to induce amnesia, piracetam (500 mg/kg, p.o.) was employed as a standard, and an ethanolic extract of Swertia chirata (50, 100, 200, 400 mg/kg) was utilized to assess nootropic activity. The Novel Object Recognition test and the elevated plus maze in AlCl3-induced amnesia models were used to evaluate the effects of medications on learning and memory in rats. This impairment is likely due to the increased vulnerability of brain cells to oxidative stress. Numerous studies have demonstrated that certain flavonoid antioxidants reduce oxidative stress-induced neuronal apoptosis. Results: Swertia chirata ethanolic extract exhibited longer exploration times for unfamiliar objects compared to familiar ones. Additionally, the ethanolic extract demonstrated a reduction in transfer latency in the elevated plus maze (EPM) in the AlCl3-induced amnesia paradigm, indicating an improvement in cognitive function. Conclusion: In experimental models, the ethanolic extract of Swertia chirata significantly (p < 0.05) reversed AlCl3-induced amnesia and improved learning and memory. The study demonstrated the neuroprotective qualities of the extract. Its anti-inflammatory and antioxidant properties may contribute to its potential in treating cognitive disorders, including dementia and Alzheimer's disease.http://www.sciencedirect.com/science/article/pii/S2666459325000101Swertia chirata, Memory impairmentAluminium chlorideAlzheimer's disease |
| spellingShingle | Reena Deshmukh Manisha Jaiswal Anshita Shukla Umesh Patil Mukesh Sharma Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride Brain Disorders Swertia chirata, Memory impairment Aluminium chloride Alzheimer's disease |
| title | Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride |
| title_full | Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride |
| title_fullStr | Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride |
| title_full_unstemmed | Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride |
| title_short | Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride |
| title_sort | cognitive enhancing effect of an extract of swertia chirata against memory impairment induced by aluminum chloride |
| topic | Swertia chirata, Memory impairment Aluminium chloride Alzheimer's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2666459325000101 |
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