Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity
Abstract Non-invasive indirect hippocampal-targeted stimulation is of broad scientific and clinical interest. Transcranial alternating current stimulation (tACS) is appealing because it allows oscillatory stimulation to study hippocampal theta (3–8 Hz) activity. We found that tACS administered durin...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Communications Psychology |
| Online Access: | https://doi.org/10.1038/s44271-025-00202-z |
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| _version_ | 1823861690568015872 |
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| author | Max Kaiser Yuejuan Wang Sanne Ten Oever Felix Duecker Alexander T. Sack Vincent van de Ven |
| author_facet | Max Kaiser Yuejuan Wang Sanne Ten Oever Felix Duecker Alexander T. Sack Vincent van de Ven |
| author_sort | Max Kaiser |
| collection | DOAJ |
| description | Abstract Non-invasive indirect hippocampal-targeted stimulation is of broad scientific and clinical interest. Transcranial alternating current stimulation (tACS) is appealing because it allows oscillatory stimulation to study hippocampal theta (3–8 Hz) activity. We found that tACS administered during functional magnetic resonance imaging yielded a frequency-, mental state- and topologically-specific effect of theta stimulation (but not other frequencies) enhancing right (but not left) hippocampal-cortical connectivity during resting blocks but not during task blocks. Control analyses showed that this effect was not due to possible stimulation-induced changes in signal quality or head movement. Our findings are promising for targeted network modulations of deep brain structures for research and clinical intervention. |
| format | Article |
| id | doaj-art-f60a377f6ca44470b5bdbbeb52b37e34 |
| institution | Kabale University |
| issn | 2731-9121 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Psychology |
| spelling | doaj-art-f60a377f6ca44470b5bdbbeb52b37e342025-02-09T12:53:13ZengNature PortfolioCommunications Psychology2731-91212025-02-013111310.1038/s44271-025-00202-zSimultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivityMax Kaiser0Yuejuan Wang1Sanne Ten Oever2Felix Duecker3Alexander T. Sack4Vincent van de Ven5Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht UniversityDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht UniversityDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht UniversityDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht UniversityDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht UniversityDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht UniversityAbstract Non-invasive indirect hippocampal-targeted stimulation is of broad scientific and clinical interest. Transcranial alternating current stimulation (tACS) is appealing because it allows oscillatory stimulation to study hippocampal theta (3–8 Hz) activity. We found that tACS administered during functional magnetic resonance imaging yielded a frequency-, mental state- and topologically-specific effect of theta stimulation (but not other frequencies) enhancing right (but not left) hippocampal-cortical connectivity during resting blocks but not during task blocks. Control analyses showed that this effect was not due to possible stimulation-induced changes in signal quality or head movement. Our findings are promising for targeted network modulations of deep brain structures for research and clinical intervention.https://doi.org/10.1038/s44271-025-00202-z |
| spellingShingle | Max Kaiser Yuejuan Wang Sanne Ten Oever Felix Duecker Alexander T. Sack Vincent van de Ven Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity Communications Psychology |
| title | Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity |
| title_full | Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity |
| title_fullStr | Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity |
| title_full_unstemmed | Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity |
| title_short | Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity |
| title_sort | simultaneous tacs fmri reveals state and frequency specific modulation of hippocampal cortical functional connectivity |
| url | https://doi.org/10.1038/s44271-025-00202-z |
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