Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease
Introduction. To determine the effect of fecal microbiota transplantation (FMT) on quality of life (QoL) in patients with inflammatory bowel disease (IBD). Methods. Fourteen IBD patients, including 11 Ulcerative colitis (UC) and 3 Crohn’s disease (CD), were treated with FMT via colonoscopy or nasoje...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/517597 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565137396989952 |
|---|---|
| author | Yao Wei Weiming Zhu Jianfeng Gong Dong Guo Lili Gu Ning Li Jieshou Li |
| author_facet | Yao Wei Weiming Zhu Jianfeng Gong Dong Guo Lili Gu Ning Li Jieshou Li |
| author_sort | Yao Wei |
| collection | DOAJ |
| description | Introduction. To determine the effect of fecal microbiota transplantation (FMT) on quality of life (QoL) in patients with inflammatory bowel disease (IBD). Methods. Fourteen IBD patients, including 11 Ulcerative colitis (UC) and 3 Crohn’s disease (CD), were treated with FMT via colonoscopy or nasojejunal tube infusion. QoL was measured by IBD Questionnaire (IBDQ). Disease activity and IBDQ were evaluated at enrollment and four weeks after treatment. Patients’ attitude concerning the treatment was also investigated. Results. One patient was excluded due to intolerance. All the other patients finished the study well. Mean Mayo score in UC patients decreased significantly (5.80 ± 1.87 versus 1.50 ± 1.35, P<0.01). Mean IBDQ scores of both UC and CD patients increased (135.50 ± 27.18 versus 177.30 ± 20.88, P=0.00063, and 107.33 ± 9.45 versus 149.00 ± 20.07, P=0.024) four weeks after fecal microbiota transplantation. There was no correlation between the IBDQ score and Mayo score before and after FMT. Patients refused to take FMT as treatment repeatedly in a short time. Conlusions. Fecal microbiota transplantation improves quality of life significantly in patients with inflammatory bowel disease. |
| format | Article |
| id | doaj-art-f6040ded80ec4d4e841ce8d415bc4598 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f6040ded80ec4d4e841ce8d415bc45982025-02-03T01:09:25ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/517597517597Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel DiseaseYao Wei0Weiming Zhu1Jianfeng Gong2Dong Guo3Lili Gu4Ning Li5Jieshou Li6Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, ChinaInstitute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, ChinaInstitute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, ChinaInstitute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, ChinaInstitute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, ChinaInstitute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, ChinaInstitute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, ChinaIntroduction. To determine the effect of fecal microbiota transplantation (FMT) on quality of life (QoL) in patients with inflammatory bowel disease (IBD). Methods. Fourteen IBD patients, including 11 Ulcerative colitis (UC) and 3 Crohn’s disease (CD), were treated with FMT via colonoscopy or nasojejunal tube infusion. QoL was measured by IBD Questionnaire (IBDQ). Disease activity and IBDQ were evaluated at enrollment and four weeks after treatment. Patients’ attitude concerning the treatment was also investigated. Results. One patient was excluded due to intolerance. All the other patients finished the study well. Mean Mayo score in UC patients decreased significantly (5.80 ± 1.87 versus 1.50 ± 1.35, P<0.01). Mean IBDQ scores of both UC and CD patients increased (135.50 ± 27.18 versus 177.30 ± 20.88, P=0.00063, and 107.33 ± 9.45 versus 149.00 ± 20.07, P=0.024) four weeks after fecal microbiota transplantation. There was no correlation between the IBDQ score and Mayo score before and after FMT. Patients refused to take FMT as treatment repeatedly in a short time. Conlusions. Fecal microbiota transplantation improves quality of life significantly in patients with inflammatory bowel disease.http://dx.doi.org/10.1155/2015/517597 |
| spellingShingle | Yao Wei Weiming Zhu Jianfeng Gong Dong Guo Lili Gu Ning Li Jieshou Li Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease Gastroenterology Research and Practice |
| title | Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease |
| title_full | Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease |
| title_fullStr | Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease |
| title_short | Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease |
| title_sort | fecal microbiota transplantation improves the quality of life in patients with inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2015/517597 |
| work_keys_str_mv | AT yaowei fecalmicrobiotatransplantationimprovesthequalityoflifeinpatientswithinflammatoryboweldisease AT weimingzhu fecalmicrobiotatransplantationimprovesthequalityoflifeinpatientswithinflammatoryboweldisease AT jianfenggong fecalmicrobiotatransplantationimprovesthequalityoflifeinpatientswithinflammatoryboweldisease AT dongguo fecalmicrobiotatransplantationimprovesthequalityoflifeinpatientswithinflammatoryboweldisease AT liligu fecalmicrobiotatransplantationimprovesthequalityoflifeinpatientswithinflammatoryboweldisease AT ningli fecalmicrobiotatransplantationimprovesthequalityoflifeinpatientswithinflammatoryboweldisease AT jieshouli fecalmicrobiotatransplantationimprovesthequalityoflifeinpatientswithinflammatoryboweldisease |