Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity
Drug delivery to wounds has developed over time from the rudimentary administration of medication on the wound or the site of infection to more sophisticated drug delivery systems. For effectively and rapidly curing wounds, a diverse range of anti-bacterial drug delivery systems must be developed. T...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Medicine in Novel Technology and Devices |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590093525000037 |
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| author | Gupta Swati Sanjaykumar Rishabha Malviya Dhanalekshmi Unnikrishnan Meenakshi Sathvik Belagodu Sridhar |
| author_facet | Gupta Swati Sanjaykumar Rishabha Malviya Dhanalekshmi Unnikrishnan Meenakshi Sathvik Belagodu Sridhar |
| author_sort | Gupta Swati Sanjaykumar |
| collection | DOAJ |
| description | Drug delivery to wounds has developed over time from the rudimentary administration of medication on the wound or the site of infection to more sophisticated drug delivery systems. For effectively and rapidly curing wounds, a diverse range of anti-bacterial drug delivery systems must be developed. The current study investigates the possibility of using an inexpensive and environment-friendly sustainable Corchorus olitorius fiber (COF) as a drug carrier for the antibacterial drug tetracycline HCl and its potential as a dressing material. The fibers were purified, grafted using acrylamide monomer, and tested for SEM, FT-IR, TGA, swelling index, swelling-de- swelling behavior, and chemical resistance. Drug loading was carried out, the highest drug loading percentage was found at 99.97 % and the formulation released medication according to the Baker-Lonsdale release kinetics pattern. The anti-microbial study showed effective inhibition of Staphylococcus aureus. The study demonstrates the successful synthesis and application of acrylamide-grafted COF loaded with tetracycline HCl, showcasing its potential as an effective wound dressing for wound care and management. Corchorus olitorius fiber is a cost-effective and eco-friendly material for preparing medicated polymeric dressings. |
| format | Article |
| id | doaj-art-f6010f171e2e4bea9f66e0ce1a8e6677 |
| institution | Kabale University |
| issn | 2590-0935 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Novel Technology and Devices |
| spelling | doaj-art-f6010f171e2e4bea9f66e0ce1a8e66772025-02-08T05:00:56ZengElsevierMedicine in Novel Technology and Devices2590-09352025-03-0125100352Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activityGupta Swati Sanjaykumar0Rishabha Malviya1Dhanalekshmi Unnikrishnan Meenakshi2Sathvik Belagodu Sridhar3Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., IndiaDepartment of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India; Corresponding author.College of Pharmacy, National University of Science and Technology, Muscat, OmanRAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab EmiratesDrug delivery to wounds has developed over time from the rudimentary administration of medication on the wound or the site of infection to more sophisticated drug delivery systems. For effectively and rapidly curing wounds, a diverse range of anti-bacterial drug delivery systems must be developed. The current study investigates the possibility of using an inexpensive and environment-friendly sustainable Corchorus olitorius fiber (COF) as a drug carrier for the antibacterial drug tetracycline HCl and its potential as a dressing material. The fibers were purified, grafted using acrylamide monomer, and tested for SEM, FT-IR, TGA, swelling index, swelling-de- swelling behavior, and chemical resistance. Drug loading was carried out, the highest drug loading percentage was found at 99.97 % and the formulation released medication according to the Baker-Lonsdale release kinetics pattern. The anti-microbial study showed effective inhibition of Staphylococcus aureus. The study demonstrates the successful synthesis and application of acrylamide-grafted COF loaded with tetracycline HCl, showcasing its potential as an effective wound dressing for wound care and management. Corchorus olitorius fiber is a cost-effective and eco-friendly material for preparing medicated polymeric dressings.http://www.sciencedirect.com/science/article/pii/S2590093525000037PurificationGraftingDrug loadingWound dressingDrug deliveryBiopolymer |
| spellingShingle | Gupta Swati Sanjaykumar Rishabha Malviya Dhanalekshmi Unnikrishnan Meenakshi Sathvik Belagodu Sridhar Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity Medicine in Novel Technology and Devices Purification Grafting Drug loading Wound dressing Drug delivery Biopolymer |
| title | Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity |
| title_full | Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity |
| title_fullStr | Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity |
| title_full_unstemmed | Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity |
| title_short | Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity |
| title_sort | corchorus olitorius jute fiber enforced sustainable polymeric dressing material for antimicrobial activity |
| topic | Purification Grafting Drug loading Wound dressing Drug delivery Biopolymer |
| url | http://www.sciencedirect.com/science/article/pii/S2590093525000037 |
| work_keys_str_mv | AT guptaswatisanjaykumar corchorusolitoriusjutefiberenforcedsustainablepolymericdressingmaterialforantimicrobialactivity AT rishabhamalviya corchorusolitoriusjutefiberenforcedsustainablepolymericdressingmaterialforantimicrobialactivity AT dhanalekshmiunnikrishnanmeenakshi corchorusolitoriusjutefiberenforcedsustainablepolymericdressingmaterialforantimicrobialactivity AT sathvikbelagodusridhar corchorusolitoriusjutefiberenforcedsustainablepolymericdressingmaterialforantimicrobialactivity |