Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication

Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication

ABSTRACT Coronaviruses (CoVs) can emerge from zoonotic sources and cause severe diseases in humans and animals. CoVs encode for a macrodomain (Mac1) that binds to and removes ADP-ribose from target proteins. SARS-CoV-2 Mac1 promotes virus replication in the presence of interferon (IFN) and blocks th...

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Main Authors: Jessica J. Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Lavinia M. Sherrill, Iain Colquhoun, Gabrielle Cadoux, Devyn Thorne, Johan Pääkkönen, Nathaniel F. Schemmel, Joseph O’Connor, Pradtahna Saenjamsai, Mei Feng, Srivatsan Parthasarathy, Michael J. Hageman, David K. Johnson, Anuradha Roy, Lari Lehtiö, Dana V. Ferraris, Anthony R. Fehr
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
SARS-CoV2
COVID-19
coronavirus
murine hepatitis virus
nsp3 macrodomain
Online Access:https://journals.asm.org/doi/10.1128/mbio.03865-24
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