Hepatobiliary organoid research: the progress and applications
Organoid culture has emerged as a forefront technology in the life sciences field. As “in vitro micro-organs”, organoids can faithfully recapitulate the organogenesis process, and conserve the key structure, physiological function and pathological state of the original tissue or organ. Consequently,...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1473863/full |
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| author | Rui-Qi Zou Rui-Qi Zou Yu-Shi Dai Yu-Shi Dai Fei Liu Fei Liu Si-Qi Yang Si-Qi Yang Hai-Jie Hu Hai-Jie Hu Fu-Yu Li Fu-Yu Li |
| author_facet | Rui-Qi Zou Rui-Qi Zou Yu-Shi Dai Yu-Shi Dai Fei Liu Fei Liu Si-Qi Yang Si-Qi Yang Hai-Jie Hu Hai-Jie Hu Fu-Yu Li Fu-Yu Li |
| author_sort | Rui-Qi Zou |
| collection | DOAJ |
| description | Organoid culture has emerged as a forefront technology in the life sciences field. As “in vitro micro-organs”, organoids can faithfully recapitulate the organogenesis process, and conserve the key structure, physiological function and pathological state of the original tissue or organ. Consequently, it is widely used in basic and clinical studies, becoming important preclinical models for studying diseases and developing therapies. Here, we introduced the definition and advantages of organoids and described the development and advances in hepatobiliary organoids research. We focus on applying hepatobiliary organoids in benign and malignant diseases of the liver and biliary tract, drug research, and regenerative medicine to provide valuable reference information for the application of hepatobiliary organoids. Despite advances in research and treatment, hepatobiliary diseases including carcinoma, viral hepatitis, fatty liver and bile duct defects have still been conundrums of the hepatobiliary field. It is necessary and crucial to study disease mechanisms, establish efficient and accurate research models and find effective treatment strategies. The organoid culture technology shed new light on solving these issues. However, the technology is not yet mature, and many hurdles still exist that need to be overcome. The combination with new technologies such as CRISPR-HOT, organ-on-a-chip may inject new vitality into future development. |
| format | Article |
| id | doaj-art-f5d6b8b859564ee6bb826ef00a3aa761 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-f5d6b8b859564ee6bb826ef00a3aa7612025-02-11T06:59:25ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.14738631473863Hepatobiliary organoid research: the progress and applicationsRui-Qi Zou0Rui-Qi Zou1Yu-Shi Dai2Yu-Shi Dai3Fei Liu4Fei Liu5Si-Qi Yang6Si-Qi Yang7Hai-Jie Hu8Hai-Jie Hu9Fu-Yu Li10Fu-Yu Li11Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaResearch Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaResearch Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaResearch Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaResearch Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaResearch Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaResearch Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaOrganoid culture has emerged as a forefront technology in the life sciences field. As “in vitro micro-organs”, organoids can faithfully recapitulate the organogenesis process, and conserve the key structure, physiological function and pathological state of the original tissue or organ. Consequently, it is widely used in basic and clinical studies, becoming important preclinical models for studying diseases and developing therapies. Here, we introduced the definition and advantages of organoids and described the development and advances in hepatobiliary organoids research. We focus on applying hepatobiliary organoids in benign and malignant diseases of the liver and biliary tract, drug research, and regenerative medicine to provide valuable reference information for the application of hepatobiliary organoids. Despite advances in research and treatment, hepatobiliary diseases including carcinoma, viral hepatitis, fatty liver and bile duct defects have still been conundrums of the hepatobiliary field. It is necessary and crucial to study disease mechanisms, establish efficient and accurate research models and find effective treatment strategies. The organoid culture technology shed new light on solving these issues. However, the technology is not yet mature, and many hurdles still exist that need to be overcome. The combination with new technologies such as CRISPR-HOT, organ-on-a-chip may inject new vitality into future development.https://www.frontiersin.org/articles/10.3389/fphar.2025.1473863/fullorganoidstem cellshepatobiliary diseasedisease modelingpersonalized medicine (PM) |
| spellingShingle | Rui-Qi Zou Rui-Qi Zou Yu-Shi Dai Yu-Shi Dai Fei Liu Fei Liu Si-Qi Yang Si-Qi Yang Hai-Jie Hu Hai-Jie Hu Fu-Yu Li Fu-Yu Li Hepatobiliary organoid research: the progress and applications Frontiers in Pharmacology organoid stem cells hepatobiliary disease disease modeling personalized medicine (PM) |
| title | Hepatobiliary organoid research: the progress and applications |
| title_full | Hepatobiliary organoid research: the progress and applications |
| title_fullStr | Hepatobiliary organoid research: the progress and applications |
| title_full_unstemmed | Hepatobiliary organoid research: the progress and applications |
| title_short | Hepatobiliary organoid research: the progress and applications |
| title_sort | hepatobiliary organoid research the progress and applications |
| topic | organoid stem cells hepatobiliary disease disease modeling personalized medicine (PM) |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1473863/full |
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