Antibiotic-resistance of H. pylori: results of microbiologic regional investigation
Aim of investigation. Development of guidelines on empirical treatment of H.pylori-associated diseases on the basis of local pattern of antibiotic-resistance.Material and methods. Overall 210 adult patients have been included in original study of H. pylori-associated diseases with positive rapid ure...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2011-03-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1389 |
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| author | N. N. Dekhnich E. A. Kostyakova A. A. Punin A. V. Alimov N. V. Ivanchik R. S. Kozlov |
| author_facet | N. N. Dekhnich E. A. Kostyakova A. A. Punin A. V. Alimov N. V. Ivanchik R. S. Kozlov |
| author_sort | N. N. Dekhnich |
| collection | DOAJ |
| description | Aim of investigation. Development of guidelines on empirical treatment of H.pylori-associated diseases on the basis of local pattern of antibiotic-resistance.Material and methods. Overall 210 adult patients have been included in original study of H. pylori-associated diseases with positive rapid urease test (Smolensk, 2009–2010). Sensitivity of H. pylori to amoxicillin, erythromycin, levofloxacin, ciprofloxacin, tetracycline and metronidazole was determined by dilution method in agar.Results. Н.pylori has been detected in 64% (n=135) patients. Previous intake of antibacterial pharmaceuticals reduced frequency of Н. pylori detection. Of 133 H. pylori strains 24 isolates (18%) were resistant to one antimicrobial agent, 4 strains (3%) were refractory to two agents and more. Frequency of resistance to macrolides was 7.6% (n=10), to metronidazole – 3.8% (n=5). No strains resistant to amoxicillin and tetracycline were revealed. Ciprofloxacin resistance level was 12.8% (n=17), that of levofloxacin – 8.3% (n=11).Conclusion. In Smolensk application of standard eradication modes of the first and second line for the treatment of Н. pylori-associated diseases is proven. The expediency of application of quinolones as back-up treatment of Н. pylori-associated diseases is doubtful in connection to rather high level of antimicrobial resistance. |
| format | Article |
| id | doaj-art-f5d4e19b49ae40a4b37d06cce81dbe5b |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2011-03-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-f5d4e19b49ae40a4b37d06cce81dbe5b2025-02-10T16:14:31ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732011-03-012123742942Antibiotic-resistance of H. pylori: results of microbiologic regional investigationN. N. DekhnichE. A. KostyakovaA. A. PuninA. V. AlimovN. V. IvanchikR. S. KozlovAim of investigation. Development of guidelines on empirical treatment of H.pylori-associated diseases on the basis of local pattern of antibiotic-resistance.Material and methods. Overall 210 adult patients have been included in original study of H. pylori-associated diseases with positive rapid urease test (Smolensk, 2009–2010). Sensitivity of H. pylori to amoxicillin, erythromycin, levofloxacin, ciprofloxacin, tetracycline and metronidazole was determined by dilution method in agar.Results. Н.pylori has been detected in 64% (n=135) patients. Previous intake of antibacterial pharmaceuticals reduced frequency of Н. pylori detection. Of 133 H. pylori strains 24 isolates (18%) were resistant to one antimicrobial agent, 4 strains (3%) were refractory to two agents and more. Frequency of resistance to macrolides was 7.6% (n=10), to metronidazole – 3.8% (n=5). No strains resistant to amoxicillin and tetracycline were revealed. Ciprofloxacin resistance level was 12.8% (n=17), that of levofloxacin – 8.3% (n=11).Conclusion. In Smolensk application of standard eradication modes of the first and second line for the treatment of Н. pylori-associated diseases is proven. The expediency of application of quinolones as back-up treatment of Н. pylori-associated diseases is doubtful in connection to rather high level of antimicrobial resistance.https://www.gastro-j.ru/jour/article/view/1389helicobacter pyloriantimicrobial resistancemacrolidesmetronidazoleamoxicillin |
| spellingShingle | N. N. Dekhnich E. A. Kostyakova A. A. Punin A. V. Alimov N. V. Ivanchik R. S. Kozlov Antibiotic-resistance of H. pylori: results of microbiologic regional investigation Российский журнал гастроэнтерологии, гепатологии, колопроктологии helicobacter pylori antimicrobial resistance macrolides metronidazole amoxicillin |
| title | Antibiotic-resistance of H. pylori: results of microbiologic regional investigation |
| title_full | Antibiotic-resistance of H. pylori: results of microbiologic regional investigation |
| title_fullStr | Antibiotic-resistance of H. pylori: results of microbiologic regional investigation |
| title_full_unstemmed | Antibiotic-resistance of H. pylori: results of microbiologic regional investigation |
| title_short | Antibiotic-resistance of H. pylori: results of microbiologic regional investigation |
| title_sort | antibiotic resistance of h pylori results of microbiologic regional investigation |
| topic | helicobacter pylori antimicrobial resistance macrolides metronidazole amoxicillin |
| url | https://www.gastro-j.ru/jour/article/view/1389 |
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