Change of Scaling-Induced Proinflammatory Cytokine on the Clinical Efficacy of Periodontitis Treatment
Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal disease, the relation...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/289647 |
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| Summary: | Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study
aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal
status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal
disease, the relationship between stimulated cytokine changes and the periodontitis treatment
outcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by
dentists as having chronic periodontitis. The proinflammatory cytokine (interleukin-1α (IL-1α),
interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit. The IL-1β and IL-6 levels increased, whereas the TNF-β levels decreased with the severity of periodontitis (4 mm pocket percentage). Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome. The differences of IL-6 levels (cut
point: 0.05 μg/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for
predicting the periodontitis treatment outcome. Among the proinflammatory cytokines, stimulated
IL-6 was an excellent marker for predicting the periodontitis treatment outcome. |
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| ISSN: | 2356-6140 1537-744X |