Afatinib boosts CAR-T cell antitumor therapeutic efficacy via metabolism and fate reprogramming

Afatinib boosts CAR-T cell antitumor therapeutic efficacy via metabolism and fate reprogramming

Background Chimeric antigen receptor T (CAR-T) cell therapy has been shown remarkable efficacy in the treatment of hematological malignancies in recent years. However, a considerable proportion of patients would experience tumor recurrence and deterioration. Insufficient CAR-T cell persistence is th...

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Bibliographic Details
Main Authors: Xi Zhang, Yue Liu, Yueyu Dai, Lingna An, Fangyuan Zhong, Shifeng Lou
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e009949.full
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