EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCER
With the help of monoclonal antibodies (MCA-1, MCA-3, G1 class immunoglobulins) and polyspecific antiserum (As) by means of immunoblotting (IB) the increase of the expression of the tumor-associated proteins (TAP) in the samples of the tumor tissues (in 94, 55 and 38% respectively), metastatic lymph...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-09-01
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| Series: | Опухоли женской репродуктивной системы |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/341 |
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| author | T. S. Bobrova K. I. Zhordania Yu. V. Chuyev |
| author_facet | T. S. Bobrova K. I. Zhordania Yu. V. Chuyev |
| author_sort | T. S. Bobrova |
| collection | DOAJ |
| description | With the help of monoclonal antibodies (MCA-1, MCA-3, G1 class immunoglobulins) and polyspecific antiserum (As) by means of immunoblotting (IB) the increase of the expression of the tumor-associated proteins (TAP) in the samples of the tumor tissues (in 94, 55 and 38% respectively), metastatic lymph nodes — LN(m+) and sera of the patients with ovarian cancer (OC) (in 82, 77 and ~100% of the cases, respectively), was detected. The important feature of As was the reactivity with the samples of the LN (m+) on the numerous proteins (>5-10) in 78% of the patients. The statistical analysis of the data using Student t-criterion revealed the significant differences (MCA-1, MCA-3) in the expression of the markers in the tumor tissues and blood sera of the oncological patients compar- ing with the samples of the adjacent tissues, blood sera of the patients with the other tumor localization and healthy donors (p<0,05). The further research using a larger amount of the clinical material and development of the more precise quantitative immunoenzyme analysis to measure TAP, is needed. It is possible that detection of TAP using MCA-1 and As may serve a basis for the creation of the test-system for the immunodiagnostics of the OC and determination of the stage of the tumor process. |
| format | Article |
| id | doaj-art-f5ae6d3a0a4e4f01afe40a07f938dcdf |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-f5ae6d3a0a4e4f01afe40a07f938dcdf2025-08-20T03:37:11ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-09-0101657210.17650/1994-4098-2008-0-1-65-72357EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCERT. S. Bobrova0K. I. Zhordania1Yu. V. Chuyev2N.N. Blokhin Cancer Research Center of Russian Academy of Medical Sciences, MoscowN.N. Blokhin Cancer Research Center of Russian Academy of Medical Sciences, MoscowN.N. Blokhin Cancer Research Center of Russian Academy of Medical Sciences, MoscowWith the help of monoclonal antibodies (MCA-1, MCA-3, G1 class immunoglobulins) and polyspecific antiserum (As) by means of immunoblotting (IB) the increase of the expression of the tumor-associated proteins (TAP) in the samples of the tumor tissues (in 94, 55 and 38% respectively), metastatic lymph nodes — LN(m+) and sera of the patients with ovarian cancer (OC) (in 82, 77 and ~100% of the cases, respectively), was detected. The important feature of As was the reactivity with the samples of the LN (m+) on the numerous proteins (>5-10) in 78% of the patients. The statistical analysis of the data using Student t-criterion revealed the significant differences (MCA-1, MCA-3) in the expression of the markers in the tumor tissues and blood sera of the oncological patients compar- ing with the samples of the adjacent tissues, blood sera of the patients with the other tumor localization and healthy donors (p<0,05). The further research using a larger amount of the clinical material and development of the more precise quantitative immunoenzyme analysis to measure TAP, is needed. It is possible that detection of TAP using MCA-1 and As may serve a basis for the creation of the test-system for the immunodiagnostics of the OC and determination of the stage of the tumor process.https://ojrs.abvpress.ru/ojrs/article/view/341 |
| spellingShingle | T. S. Bobrova K. I. Zhordania Yu. V. Chuyev EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCER Опухоли женской репродуктивной системы |
| title | EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCER |
| title_full | EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCER |
| title_fullStr | EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCER |
| title_full_unstemmed | EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCER |
| title_short | EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCER |
| title_sort | expression of the tumor associated proteins in the ovarian cancer |
| url | https://ojrs.abvpress.ru/ojrs/article/view/341 |
| work_keys_str_mv | AT tsbobrova expressionofthetumorassociatedproteinsintheovariancancer AT kizhordania expressionofthetumorassociatedproteinsintheovariancancer AT yuvchuyev expressionofthetumorassociatedproteinsintheovariancancer |