Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract.
Tinospora cordifolia extract exhibits diverse benefits-anti-arthritis, anti-malarial, anti-allergic, anti-diabetic, antihepatotoxic, and antipyretic effects. Its specific anti-inflammatory and healing capacities remain unexplored, prompting a study utilizing a mouse skin wound model and direct T. co...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317928 |
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| author | Shohag Chandra Das Subrato Biswas Olin Khan Rupa Akter Md Abul Kalam Azad Sujan Kumar Sarkar Md Abdul Masum Sultana Bedoura |
| author_facet | Shohag Chandra Das Subrato Biswas Olin Khan Rupa Akter Md Abul Kalam Azad Sujan Kumar Sarkar Md Abdul Masum Sultana Bedoura |
| author_sort | Shohag Chandra Das |
| collection | DOAJ |
| description | Tinospora cordifolia extract exhibits diverse benefits-anti-arthritis, anti-malarial, anti-allergic, anti-diabetic, antihepatotoxic, and antipyretic effects. Its specific anti-inflammatory and healing capacities remain unexplored, prompting a study utilizing a mouse skin wound model and direct T. cordifolia extraction. UV-Vis spectroscopy depicted an absorption range of 200-400 nm, while FTIR analysis identified alcohols, phenols, amines, amides, aldehydes, ketones, alkanes, and alkenes. GC-MS analysis revealed the presence of components: 5methyl-5-Hexen-2-Ol, n-hexadecenoic acid, cholesta-4,6-dien-3beta-ol, stigmasterol, β-sitosterol, stearate which are present in the extract. Histopathological examination confirmed accelerated wound healing, showcasing reduced inflammation, restored blood vessels, collagen fibers, and swift epidermal closure. T. cordifolia extract exhibits promise in enhancing wound healing through its antibacterial, anti-inflammatory properties. |
| format | Article |
| id | doaj-art-f5a23bf74cbb4c6ea7375c75534981ac |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-f5a23bf74cbb4c6ea7375c75534981ac2025-02-07T05:30:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031792810.1371/journal.pone.0317928Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract.Shohag Chandra DasSubrato BiswasOlin KhanRupa AkterMd Abul Kalam AzadSujan Kumar SarkarMd Abdul MasumSultana BedouraTinospora cordifolia extract exhibits diverse benefits-anti-arthritis, anti-malarial, anti-allergic, anti-diabetic, antihepatotoxic, and antipyretic effects. Its specific anti-inflammatory and healing capacities remain unexplored, prompting a study utilizing a mouse skin wound model and direct T. cordifolia extraction. UV-Vis spectroscopy depicted an absorption range of 200-400 nm, while FTIR analysis identified alcohols, phenols, amines, amides, aldehydes, ketones, alkanes, and alkenes. GC-MS analysis revealed the presence of components: 5methyl-5-Hexen-2-Ol, n-hexadecenoic acid, cholesta-4,6-dien-3beta-ol, stigmasterol, β-sitosterol, stearate which are present in the extract. Histopathological examination confirmed accelerated wound healing, showcasing reduced inflammation, restored blood vessels, collagen fibers, and swift epidermal closure. T. cordifolia extract exhibits promise in enhancing wound healing through its antibacterial, anti-inflammatory properties.https://doi.org/10.1371/journal.pone.0317928 |
| spellingShingle | Shohag Chandra Das Subrato Biswas Olin Khan Rupa Akter Md Abul Kalam Azad Sujan Kumar Sarkar Md Abdul Masum Sultana Bedoura Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract. PLoS ONE |
| title | Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract. |
| title_full | Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract. |
| title_fullStr | Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract. |
| title_full_unstemmed | Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract. |
| title_short | Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract. |
| title_sort | evaluation of anti inflammatory and wound healing properties of tinospora cordifolia extract |
| url | https://doi.org/10.1371/journal.pone.0317928 |
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