Maturation of small nucleolar RNAs: from production to function
Small Nucleolar RNAs (snoRNAs) are an abundant group of non-coding RNAs with well-defined roles in ribosomal RNA processing, folding and chemical modification. Besides their classic roles in ribosome biogenesis, snoRNAs are also implicated in several other cellular activities including regulation of...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2023.2254540 |
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| author | Sarah F. Webster Homa Ghalei |
| author_facet | Sarah F. Webster Homa Ghalei |
| author_sort | Sarah F. Webster |
| collection | DOAJ |
| description | Small Nucleolar RNAs (snoRNAs) are an abundant group of non-coding RNAs with well-defined roles in ribosomal RNA processing, folding and chemical modification. Besides their classic roles in ribosome biogenesis, snoRNAs are also implicated in several other cellular activities including regulation of splicing, transcription, RNA editing, cellular trafficking, and miRNA-like functions. Mature snoRNAs must undergo a series of processing steps tightly regulated by transiently associating factors and coordinated with other cellular processes including transcription and splicing. In addition to their mature forms, snoRNAs can contribute to gene expression regulation through their derivatives and degradation products. Here, we review the current knowledge on mechanisms of snoRNA maturation, including the different pathways of processing, and the regulatory mechanisms that control snoRNA levels and complex assembly. We also discuss the significance of studying snoRNA maturation, highlight the gaps in the current knowledge and suggest directions for future research in this area. |
| format | Article |
| id | doaj-art-f58ab805ca054f03a76fc3fb0a1df7fc |
| institution | OA Journals |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-f58ab805ca054f03a76fc3fb0a1df7fc2025-08-20T02:01:24ZengTaylor & Francis GroupRNA Biology1547-62861555-85842023-12-0120171573610.1080/15476286.2023.2254540Maturation of small nucleolar RNAs: from production to functionSarah F. Webster0Homa Ghalei1Biochemistry, Cell, and Developmental Biology Graduate Program, Emory University, Atlanta, Georgia, USADepartment of Biochemistry, Emory University, Atlanta, Georgia, USASmall Nucleolar RNAs (snoRNAs) are an abundant group of non-coding RNAs with well-defined roles in ribosomal RNA processing, folding and chemical modification. Besides their classic roles in ribosome biogenesis, snoRNAs are also implicated in several other cellular activities including regulation of splicing, transcription, RNA editing, cellular trafficking, and miRNA-like functions. Mature snoRNAs must undergo a series of processing steps tightly regulated by transiently associating factors and coordinated with other cellular processes including transcription and splicing. In addition to their mature forms, snoRNAs can contribute to gene expression regulation through their derivatives and degradation products. Here, we review the current knowledge on mechanisms of snoRNA maturation, including the different pathways of processing, and the regulatory mechanisms that control snoRNA levels and complex assembly. We also discuss the significance of studying snoRNA maturation, highlight the gaps in the current knowledge and suggest directions for future research in this area.https://www.tandfonline.com/doi/10.1080/15476286.2023.2254540Small nucleolar RNAsnoRNAsnoRNA maturationsnoRNP assemblynon-coding RNA processing |
| spellingShingle | Sarah F. Webster Homa Ghalei Maturation of small nucleolar RNAs: from production to function RNA Biology Small nucleolar RNA snoRNA snoRNA maturation snoRNP assembly non-coding RNA processing |
| title | Maturation of small nucleolar RNAs: from production to function |
| title_full | Maturation of small nucleolar RNAs: from production to function |
| title_fullStr | Maturation of small nucleolar RNAs: from production to function |
| title_full_unstemmed | Maturation of small nucleolar RNAs: from production to function |
| title_short | Maturation of small nucleolar RNAs: from production to function |
| title_sort | maturation of small nucleolar rnas from production to function |
| topic | Small nucleolar RNA snoRNA snoRNA maturation snoRNP assembly non-coding RNA processing |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2023.2254540 |
| work_keys_str_mv | AT sarahfwebster maturationofsmallnucleolarrnasfromproductiontofunction AT homaghalei maturationofsmallnucleolarrnasfromproductiontofunction |