BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma

BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma

Abstract Background Bladder cancer (BLCA) represents one of the most prevalent urological malignancies worldwide. Bridging integrator 1 (BIN1), a well-characterized tumor suppressor that interacts with and inhibits oncogenic Myc transcription factors, has demonstrated crucial roles in various cancer...

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Main Authors: Si-yu Chen, Ya-long Zhang, Xiao-ran Li, Ji-rong Wang, Kun-peng Li, Shun Wan, Jian-wei Yang, Hao Wang, Jin-long Cao, Chen-yang Wang, Xin-peng Fan, Sheng-jun Fu, Li-yun Ding, Tuan-jie Che, Li Yang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Hereditas
Subjects:
BIN1
Bladder cancer
Cancer stem cells
ALDH1
NOTCH, EMT
Online Access:https://doi.org/10.1186/s41065-025-00384-w
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