Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods

Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods

Military service members (SMs) and veterans who have sustained one or more concussions during their service have significantly higher rates of persistent depressive symptoms and suicidality compared to non-injured peers. Despite over 500,000 SMs who have sustained concussions, there are currently no...

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Bibliographic Details
Main Authors: Lindsay M. Oberman, Adriana I. Penafiel, Rachel Dieterich, Cuong T. Phan, Yi-Yu Chou, Dzung L. Pham, Maheen M. Adamson, Christopher E. Hines, Zeynab Rezaee, Zhi-De Deng, Hemant Pal, Sarah H. Lisanby, David L. Brody
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neurology
Subjects:
concussion
major depressive disorder
accelerated intermittent theta burst stimulation
traumatic brain injury
transcranial magnetic stimulation
Bayesian adaptive trial
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1605157/full
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